11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
- Product Name
- 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
- CAS No.
- 123548-16-3
- Chemical Name
- 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
- Synonyms
- AQ-RA 741;11-[[4-[4-(Diethylamino)butyl]piperidin-1-yl]acetyl]-11H-pyrido[2,3-b][1,4]benzodiazepin-6(5H)-one;11-(2-(4-(4-(Diethylamino)butyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one;11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE;5,11-Dihydro-11-[[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one;6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 11-[2-[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-
- CBNumber
- CB5840317
- Molecular Formula
- C27H37N5O2
- Formula Weight
- 463.61
- MOL File
- 123548-16-3.mol
11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Property
- Boiling point:
- 602.7±50.0 °C(Predicted)
- Density
- 1.132±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- <46.36mg/ml in 1eq. HCl; <46.36mg/ml in ethanol; <46.36mg/ml in DMSO
- form
- solid
- pka
- 11.29±0.20(Predicted)
- color
- White
N-Bromosuccinimide Price
- Product number
- 2292
- Product name
- AQ-RA741
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 2292
- Product name
- AQ-RA741
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $683
- Updated
- 2021/12/16
- Product number
- A735440
- Product name
- AQ-RA741
- Packaging
- 50mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 254659
- Product name
- AQ-RA 741
- Packaging
- 10mg
- Price
- $409
- Updated
- 2021/12/16
- Product number
- CHM0998849
- Product name
- 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.26
- Updated
- 2021/12/16
11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Chemical Properties,Usage,Production
Uses
AQ-RA 741 acts as a potent and highly specific muscarinic M2 receptor antagonist, with potential application towards the development of bronchodilator anti-muscarinic agents for humans.
Definition
ChEBI: 11-[2-[4-[4-(diethylamino)butyl]-1-piperidinyl]-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one is a benzodiazepine.
Biological Activity
High affinity, selective muscarinic M 2 receptor antagonist (pK i values are 8.3, 7.7 and 6.82 for M 2 , M 1 and M 3 receptors, respectively). In vivo, displays cardioselectivity over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.
storage
Store at RT
References
[1]. doods h, entzeroth m and mayer n. cardioselectivity of aq-ra 741, a novel tricyclic antimuscarinic drug. eur j pharmacol, 1991, 192(1):147-52.
[2]. gomeza j, shannon h, kostenis e, et al. pronounced pharmacologic deficits in m2 muscarinic acetylcholine receptor knockout mice. proc natl acad sci u s a, 1999, 96(4):1692-7.