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ISOXAZOLE, 4-NITRO-

Product Name
ISOXAZOLE, 4-NITRO-
CAS No.
1121-13-7
Chemical Name
ISOXAZOLE, 4-NITRO-
Synonyms
4-Nitroisoxazole;4-nitro-1,2-oxazole;ISOXAZOLE, 4-NITRO-
CBNumber
CB5840337
Molecular Formula
C3H2N2O3
Formula Weight
114.06
MOL File
1121-13-7.mol
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ISOXAZOLE, 4-NITRO- Property

Melting point:
46-47 °C
Boiling point:
243.5±13.0 °C(Predicted)
Density 
1.475±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-5.58±0.50(Predicted)
Appearance
Light brown to brown Solid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
N901073
Product name
4-Nitroisoxazole
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
X8994
Product name
4-Nitroisoxazole
Packaging
250mg
Price
$188
Updated
2021/12/16
Apolloscientific
Product number
OR904227
Product name
4-Nitroisoxazole
Purity
96%
Packaging
1g
Price
$327
Updated
2021/12/16
AK Scientific
Product number
X8994
Product name
4-Nitroisoxazole
Packaging
1g
Price
$355
Updated
2021/12/16
Matrix Scientific
Product number
072478
Product name
4-Nitroisoxazole
Purity
95+%
Packaging
250mg
Price
$416
Updated
2021/12/16
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ISOXAZOLE, 4-NITRO- Chemical Properties,Usage,Production

Synthesis

288-14-2

1121-13-7

General procedure for the synthesis of 4-nitroisoxazole from isoxazole: ammonium nitrate (1.8 g, 22.5 mmol) was added to a solution of trifluoroacetic anhydride (7 mL, 50.7 mmol) of isoxazole (1 g, 14.5 mmol) in batches of 0.3 g each, and the temperature of the reaction was controlled to be between 25 and 30 °C. After the addition was completed, the reaction mixture was slowly poured into ice water and extracted with dichloromethane (15 mL x 4). The organic phases were combined, washed with water and the aqueous layer was then extracted with dichloromethane. The combined dichloromethane extracts were dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a yellow-green oil. The oily material was ground with hexane under the condition of cooling to 50 ℃, a solid was precipitated, and 4-nitroisoxazole was obtained by filtration (0.72 g, 44% yield).

References

[1] Journal of Organic Chemistry, 1987, vol. 52, # 13, p. 2714 - 2726
[2] Helvetica Chimica Acta, 1989, vol. 72, p. 556 - 569
[3] Patent: WO2009/154769, 2009, A1. Location in patent: Page/Page column 37-38
[4] Zhurnal Obshchei Khimii, 1959, vol. 29, p. 535,538; engl. Ausg. S. 533
[5] Patent: WO2011/38572, 2011, A1. Location in patent: Page/Page column 76

ISOXAZOLE, 4-NITRO- Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOXAZOLE, 4-NITRO- Suppliers

China 27 France 1 Germany 1 India 1 United States 5 Global 35
Pure Chemistry Scientific Inc.
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China
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China DongFan Chemical Co.,LTD
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86-0571-85151182
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China
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Hangzhou Sage Chemical Co., Ltd.
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1121-13-7, ISOXAZOLE, 4-NITRO-Related Search:

3-METHYL-4-NITROISOXAZOL-5-AMINE 3,5-DIMETHYL-4-NITROISOXAZOLE 2,4-DIFLUORO-N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]ANILINE 4-CHLORO-2-([2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]AMINO)BENZENOL 2-[2-(3-METHYL-4-NITROISOXAZOL-5-YL)VINYL]THIOPHENE-3-CARBOXALDEHYDE 1-(4-CHLOROPHENYL)-3-(2-[2-(3-METHYL-4-NITROISOXAZOL-5-YL)VINYL]-3-THIENYL)PROP-2-EN-1-ONE RARECHEM AL BP 0988 N1-(3-METHYL-4-NITROISOXAZOL-5-YL)-2-CHLOROACETAMIDE 3-METHYL-N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]ANILINE N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]-3-(METHYLSULFANYL)ANILINE 2-METHOXY-N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]ANILINE N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]-4-PHENOXYANILINE 3,4-DIMETHYL-N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]ANILINE 4-METHYL-N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]ANILINE 4-CHLORO-N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]ANILINE 4-([2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]AMINO)BENZENECARBOXYLIC ACID 3,5-DICHLORO-N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]ANILINE N-[2-(3-METHYL-4-NITRO-5-ISOXAZOLYL)VINYL]-N-PHENYLAMINE

  • ISOXAZOLE, 4-NITRO-
  • 4-Nitroisoxazole
  • 4-nitro-1,2-oxazole
  • 1121-13-7
  • 1121-41-7