1H-IMIDAZOLE-2-CARBONITRILE
- Product Name
- 1H-IMIDAZOLE-2-CARBONITRILE
- CAS No.
- 31722-49-3
- Chemical Name
- 1H-IMIDAZOLE-2-CARBONITRILE
- Synonyms
- 2CNZ;2-Cyanoimidazole;1H-Imidazol-2-carbonitrile;1H-IMIDAZOLE-2-CARBONITRILE;1H-Imidazole-2-carbonitri...
- CBNumber
- CB5847497
- Molecular Formula
- C4H3N3
- Formula Weight
- 93.09
- MOL File
- 31722-49-3.mol
1H-IMIDAZOLE-2-CARBONITRILE Property
- Melting point:
- 176-177 °C(Solv: benzene (71-43-2))
- Boiling point:
- 276.0±23.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.51±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3H37-1-2W
- Product name
- 1H-Imidazole-2-carbonitrile
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 3H37-1-2W
- Product name
- 1H-Imidazole-2-carbonitrile
- Packaging
- 1g
- Price
- $625
- Updated
- 2021/12/16
- Product number
- 085415
- Product name
- 1H-Imidazol-2-carbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $727
- Updated
- 2021/12/16
- Product number
- 3456AB
- Product name
- 1H-Imidazole-2-carbonitrile
- Packaging
- 5g
- Price
- $851
- Updated
- 2021/12/16
- Product number
- 3456AB
- Product name
- 1H-Imidazole-2-carbonitrile
- Packaging
- 10g
- Price
- $1451
- Updated
- 2021/12/16
1H-IMIDAZOLE-2-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
10111-08-7
31722-49-3
General procedure for the synthesis of 1H-imidazole-2-carbonitrile from 2-imidazolecarboxaldehyde: To a 1L round-bottomed flask was added a solution of 1H-imidazole-2-carboxaldehyde (5 g, 52.04 mmol) in N,N-dimethylformamide (200 mL). Triethylamine (10.8 mL, 77.97 mmol), hydroxylamine hydrochloride (3.95 g, 56.84 mmol, 1.10 eq.) and 1-propanephosphonic anhydride solution (T3P, 36.4 g, 114.40 mmol) were added sequentially. The reaction mixture was stirred at 100 °C for 4 h. After cooling, the reaction was quenched with 500 mL of ice water. The aqueous phase was extracted with ethyl acetate (3 x 1 L), the combined organic layers were washed with brine (2 x 1 L), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent of ethyl acetate/petroleum ether (1/2) to give 2 g (41%) of the target product 1H-imidazole-2-carbonitrile as an off-white solid.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 27, p. 3421 - 3424
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3038 - 3041
[3] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 271; 272
[4] Patent: WO2012/85038, 2012, A1. Location in patent: Page/Page column 39
1H-IMIDAZOLE-2-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-IMIDAZOLE-2-CARBONITRILE manufacturers
- Product
- 1H-IMIDAZOLE-2-CARBONITRILE 31722-49-3
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-21