2,6-Dichlorothiobenzamide

2,6-Dichlorothiobenzamide Property

Melting point:

151-152°C

Boiling point:

320.6±52.0 °C(Predicted)

Density 

1.4704 (rough estimate)

refractive index 

1.6300 (estimate)

Flash point:

>100 °C

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

11.71±0.29(Predicted)

color 

White to Pale Beige

Water Solubility 

0.95g/L(21 ºC)

BRN 

1910353

CAS DataBase Reference

1918-13-4(CAS DataBase Reference)

EPA Substance Registry System

Chlorthiamid (1918-13-4)

Safety

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

1

RTECS 

CV3850000

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

2930909899

Toxicity

LD50 oral in rabbit: 300mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

2,6-Dichlorothiobenzamide Chemical Properties,Usage,Production

Uses

Refer to the productμs Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Definition

ChEBI: 2,6-dichlorothiobenzamide is a dichlorobenzene and a thiocarboxamide. It has a role as a proherbicide and an agrochemical.

Safety Profile

Poison by ingestion and intraperitoneal route. Moderately toxic by skin contact. Mutation data reported. An herbicide. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and sox.

Metabolic pathway

Twelve metabolites are isolated from either urine or bile from either rats (11 metabolites) or goats (seven metabolites) given single oral doses of 14C-labeled 2,6-dichlorobenzonitrile (DCBN). Five of these metabolites are also excreted in urine from rats dosed orally with 2,6-dichlorothiobenzamide (DCTBA) which is an acid amide analog. All metabolites from either DCBN or DCTBA are benzonitriles with the following ring substituents: Cl2, OH (three isomers); Cl2, (OH)2; Cl, (OH)2; Cl, OH, SH; Cl, OH, SCH3; SOCH3, OH; Cl2, S-(N-acetyl)cysteine; Cl, S-(N-acetyl)cysteine; Cl, OH, S-(N-acetyl)cysteine.
The thiobenzamide moiety of DCTBA is converted to the nitrile in all extracted urinary metabolites. No hydrolysis of the nitrile in DCBN to either amide or an acid is detected. Urine is the major route for excretion; however, enterohepatic circulation occurs.