1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine
- Product Name
- 1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine
- CAS No.
- 340041-91-0
- Chemical Name
- 1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine
- Synonyms
- AP-1;AH119;MFCD09952023;NF-κB (p49) human;C-jun, proto oncogene human;c-JUN (1-79), GST tagged human;Anti-FOS antibody produced in goat;1-((4-Nitrobenzyl)sulfonyl)pyrrolidine;4-(Pyrrolidino sulfonyl methyl)nitrobenzene;1-(4-Nitrophenylmethanesulfonyl)pyrrolidine
- CBNumber
- CB5855300
- Molecular Formula
- C11H14N2O4S
- Formula Weight
- 270.3
- MOL File
- 340041-91-0.mol
1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine Property
- Density
- 1.41
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMF: 30 mg/ml
DMSO: 30 mg/ml - form
- frozen liquid
- color
- clear
colorless - biological source
- mouse
Safety
- Safety Statements
- 23-24/25
N-Bromosuccinimide Price
- Product number
- SRP2088
- Product name
- C-jun, proto oncogene human
- Purity
- recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
- Packaging
- 5 μg
- Price
- $536
- Updated
- 2025/07/31
- Product number
- SAB2502116
- Product name
- Anti-FOS antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100 μg
- Price
- $586
- Updated
- 2025/07/31
- Product number
- CHM0078545
- Product name
- N-[(4-NITROPHENYL)-METHYLSULFONYL]PYRYOLIDINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- R051
- Product name
- N-[(4-Nitrophenyl)methylsulfonyl]pyryolidine
- Packaging
- 250g
- Price
- $1084
- Updated
- 2021/12/16
- Product number
- 340041910
- Product name
- 1-((4-Nitrobenzyl)sulfonyl)pyrrolidine
- Packaging
- 5g
- Price
- $436.72
- Updated
- 2021/12/16
1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine Chemical Properties,Usage,Production
Uses
cell analysis
Biological Activity
The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. AP-1 and nuclear factor B (NF- B) can be specifically targeted to prevent cancer induction in mouse models. AP-1 can be produced by 18 different dimeric combinations of proteins from the Jun (c-Jun, JunB and JunD) and Fos (c-Fos, FosB, Fra-1 and Fra-2) families, including Jun homodimers and Jun-Fos heterodimers. The Jun and Fos proteins contain a basic-region leucine zipper (bZIP) domain, and are capable of binding to other bZIP proteins including those from the ATF, MAF, CNC and C/EBP (CCAAT/enhancer-binding protein) subfamilies (5]) Jun-Jun and Jun-Fos dimers bind with highest affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE) [TGA(C/G)TCA], although many other μAP-1-like sitesμ have been reported. Binding to any of these sites can be tissue-specific, or affected by neighboring sequences, and dependent upon interactions with other transcription factors or cofactors. Jun and Fos proteins can also dimerize with other bZIP proteins, allowing them to target other DNA binding sites, such as the cAMP response element (CRE), the antioxidant response elements (ARE), and half-sites composed of half of a TRE site and half of a MAF- or CNC-binding site. In addition, AP-1 proteins can interact with other proteins, including the p65 subunit of NF- B, CBP (CRE-binding-protein-binding protein) (p300), SMAD-3 and -4, and the retinoblastoma protein (see 5 for a more complete list), further increasing the combinatorial potential of Jun and Fos proteins. AP-1 regulates a variety of cellular processes, including proliferation, differentiation and apoptosis, and contributes to both basal and stimulus-activated gene expression. It is activated by growth factors, hormones, stress, cytokines, ROS and ultraviolet radiation Activation occurs both transcriptionally and post-translationally, and is signaled predominantly through the mitogen-activated protein kinase (MAPK) cascade. The combinatorial diversity of AP-1 proteins and other interacting factors appears to influence how specific cell types respond to a stimulus. The growth-promoting activity of c-Jun is mediated by repression of tumor suppressors, as well as up-regulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect.
References
[1] LIDONG GONG . Discovery of a miniaturized PROTAC with potent activity and high selectivity[J]. Bioorganic Chemistry, 2023, 136: Article 106556. DOI: 10.1016/j.bioorg.2023.106556
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View Lastest Price from 1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine manufacturers
- Product
- 1-[(4-Nitrobenzyl)sulfonyl]pyrrolidine 340041-91-0
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-29
- Product
- 1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine 340041-91-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-20
- Product
- 1-[[(4-Nitrophenyl)methyl]sulfonyl]-pyrrolidine 340041-91-0
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21