Guanadrel

Product Name: Guanadrel
CAS No.: 40580-59-4
Chemical Name: Guanadrel
Synonyms: C07035;Guanadrel;Guanadrel USP/EP/BP;N-(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine;1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine;2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine;Guanidine, N-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-;2-((1,4-dioxaspiro[4.5]decan-2-yl)methyl)guanidine
CBNumber: CB5875306
Molecular Formula: C10H19N3O2
Formula Weight: 213.28
MOL File: 40580-59-4.mol

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Guanadrel Property

Boiling point:: 341.5±40.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
form: A solid
pka: 12.59±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0011591
Product name: GUANADREL
Purity: 95.00%
Packaging: 5MG
Price: $497.92
Updated: 2021/12/16

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Guanadrel Chemical Properties,Usage,Production

Description

Guanadrel is an adrenergic neuron blocker used for essential hypertension. Its mechanism of action and side effects are similar to those of guanethidine.

Originator

Hylorel,Pennwalt,US,1983

Uses

It is used to treat hypertension in patients who do not adequately respond to thiazide diuretics. It can be used as an adjuvant in thiazide treatment for reaching an optimal level of blood pressure.

Uses

Antihypertensive.

Uses

Guanadrel is an adrenergic neuron blocker used for essential hypertension. The mechanism of action and side effects are similar to guanethidine. It is used for treating hypertension in patients who do not respond to thiazide diuretics. It can be used as an adjuvant drug in thiazide treatment for reaching an optimal level of blood pressure.

Definition

ChEBI: A spiroketal resulting from the formal condensation of the keto group of cyclohexanone with the hydroxy groups of 1-(2,3-dihydroxypropyl)guanidine. A postganglionic adrenergic blocking agent formerly used (generally as the sulfate salt) for the management f hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching).

Manufacturing Process

A mixture of 10.5 g of 1,4-dioxaspiro[4.5]decane-2-methylamine and 8.6 g of 2-methyl-2-thiopseudourea sulfate in 40 ml of water was heated on the steam bath for 4 hours during which 2.0 g of methylmercaptan was collected in a dry ice bath connected to the reaction flask through a water cooled reflux condenser. The reaction mixture was then evaporated at 15 mm pressure to a solid residue which was then dissolved in 80 ml of 50/50 methanol-ethanol. The solution was filtered and evaporated to approximately 50 ml volume and allowed to cool and crystallize, giving a crop melting at 213.5°C to 215°C of 1,4-dioxaspiro[4.5]decan-2-ylmethyl)-guanidine sulfate.

brand name

Hylorel (Pharmacia & Upjohn).

Therapeutic Function

Antihypertensive

Synthesis

Guanadrel, (1,4-dioxaspiro[4,5]dec-2-ylmethyl)guanidine (12.3.8), is synthesized when cyclohexanone undergoes ketalization by 3-chloro-1,2-proandiol, forming 2- chloromethyl-1,4-dioxyspiro[4,5]decane (12.3.5), which is further akylated by sodium phthalimide. After alkyline hydrazinolysis, the resulting phthalimide derivative (12.3.6) is transformed into 2-aminomethyl-1,4-dioxyspiro[4,5]decane (12.3.7), which is reacted with S-methylthiourea, giving the desired guanadrel (12.3.8) [80¨C82].

Guanadrel Preparation Products And Raw materials

Raw materials

Preparation Products

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Guanadrel Suppliers

China 16 United Kingdom 1 United States 5 Global 22

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9382
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28557
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 9126
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

Amel Pharmatech Corporation

Tel: 888-4366503
Fax: 888-502-1736
Email: sales@amelpharmatech.com
Country: China
ProdList: 5351
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28180
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3553
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 39997
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 6975
Advantage: 58

Aribo Pharmatech Co., Ltd.

Tel: 19951442182
Email: sales@aribopharm.com
Country: China
ProdList: 2499
Advantage: 58

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View Lastest Price from Guanadrel manufacturers

Dideu Industries Group Limited

Product: Guanadrel 40580-59-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-10

Shaanxi Dideu Medichem Co. Ltd

Product: Guanadrel 40580-59-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

40580-59-4, GuanadrelRelated Search:

(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE Guanadrel Guanadrel HeMisulfate 2-methyl-1,4-dioxaspiro[4.5]decane 1,4-Dioxaspiro[4.5]decane-2-methanamine

2-((1,4-dioxaspiro[4.5]decan-2-yl)methyl)guanidine

2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine

Guanadrel

1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine

C07035

N-(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine

Guanidine, N-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)-

Guanadrel USP/EP/BP

40580-59-4