4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate

Product Name: 4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate
CAS No.: 6823-79-6
Chemical Name: 4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate
Synonyms: Lomidine;pentamidine mesylate;Pentamidine dimesylate;PENTAMIDINE DIMETHANESULFONATE;4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate
CBNumber: CB5890857
Molecular Formula: C21H32N4O8S2
Formula Weight: 532.63078
MOL File: 6823-79-6.mol

More

Less

Safety

RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0016849
Product name: PENTAMIDINE DIMETHANESULFONATE
Purity: 95.00%
Packaging: 5MG
Price: $497.57
Updated: 2021/12/16

More

Less

4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Chemical Properties,Usage,Production

Uses

Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

in vivo

Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) dimesylate treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice^[1].

Animal Model:	Athymic nude mice (6 weeks old) injected with WM9 cells^[1]
Dosage:	0.25 mg/mouse
Administration:	Intramuscular injection; every 2 days; for 4 weeks
Result:	Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.

IC 50

Trypanosoma; Leishmania

References

[1] Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PMID:12516958
[2] Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. DOI:10.1002/cbdv.200590111
[3] Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34. DOI:10.1093/clinids/7.5.625
[4] David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.

4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Suppliers

China 2 United States 3 Global 5

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

6823-79-6, 4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonateRelated Search:

4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Pentamidine isethionate Pentamidine

4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate

PENTAMIDINE DIMETHANESULFONATE

pentamidine mesylate

Lomidine

Pentamidine dimesylate

6823-79-6

C19H24N4O22CH4O3S