N-(2-hydroxyethyl)acetoacetamide
- Product Name
- N-(2-hydroxyethyl)acetoacetamide
- CAS No.
- 24309-97-5
- Chemical Name
- N-(2-hydroxyethyl)acetoacetamide
- Synonyms
- -(N-Acetoacetylamino)ethanol;β-(N-Acetoacetylamino)ethanol;Acetoacet-N-hydroxyethylamide;beta-(N-Acetoacetylamino)ethanol;N-(2-Hydroxyethyl)-3-oxobutanamide;N-(2-Hydroxy-ethyl)-3-oxo-butyramide;N-(2-hydroxyethyl)-3-keto-butyramide;Butanamide, N-(2-hydroxyethyl)-3-oxo-
- CBNumber
- CB5893005
- Molecular Formula
- C6H11NO3
- Formula Weight
- 145.16
- MOL File
- 24309-97-5.mol
N-(2-hydroxyethyl)acetoacetamide Property
- Melting point:
- 104-106 °C
- Boiling point:
- 373.7±27.0 °C(Predicted)
- Density
- 1.132±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.48±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A161810
- Product name
- β-(N-Acetoacetylamino)ethanol
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- CHM1049668
- Product name
- N-(2-HYDROXYETHYL)ACETOACETAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $454.91
- Updated
- 2021/12/16
- Product number
- 6211CA
- Product name
- N-(2-Hydroxyethyl)-3-oxobutanamide
- Packaging
- 5g
- Price
- $861
- Updated
- 2021/12/16
- Product number
- CD13017461
- Product name
- N-(2-Hydroxyethyl)-3-oxobutanamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1535
- Updated
- 2021/12/16
- Product number
- CD13017461
- Product name
- N-(2-Hydroxyethyl)-3-oxobutanamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $446
- Updated
- 2021/12/16
N-(2-hydroxyethyl)acetoacetamide Chemical Properties,Usage,Production
Chemical Properties
Yellow to brownisch solidifed melt
Uses
N-(2-Hydroxyethyl)acetoacetamide is used as intermediate for the syntheses of different organic chemicals, e.g. quinoxaline derivatives. Product Data Sheet
Synthesis
674-82-8
141-43-5
24309-97-5
General procedure for the synthesis of N-(2-hydroxyethyl)-3-oxobutanamide from bis(vinylidene) ketone and 2-aminoethanol: 23 mL (0.38 mol) of 2-aminoethanol was added slowly and dropwise to 30 g (0.36 mol) of bis(vinylidene) ketone dissolved in 300 mL of tetrahydrofuran at -5 to 0 °C. The reaction mixture was stirred at 0 °C for 1 h. Complete consumption of the feedstock was confirmed by thin layer chromatography (TLC) monitoring. Subsequently, the solvent was removed by evaporation and the residue was purified by column chromatography. Finally, 41.44 g (0.29 mol, 80% yield) of the target compound was obtained as a white solid. The product was identified by infrared spectroscopy (IR, neat, cm?1) showing characteristic absorption peaks: 3273, 3097, 2973, 2938, 2880, 1710, 1646, 1558, 1494, 1465, 1420, 1362, 1347, 1312, 1297, 1215, 1190, 1166, 1052, 1038. (2H), 3.4 (4H), 2.2 (3H).
References
[1] Patent: US2013/109662, 2013, A1. Location in patent: Paragraph 0394; 0395; 0396; 0397; 0398; 0399
[2] Heterocycles, 1995, vol. 41, # 10, p. 2203 - 2220
N-(2-hydroxyethyl)acetoacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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