4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

Product Name: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
CAS No.: 66000-40-6
Chemical Name: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine
Synonyms: BW-755C;CGS-13592;3-amino-1--2-pyrazoline;2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine;4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine;1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine;1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-
CBNumber: CB5898606
Molecular Formula: C10H10F3N3
Formula Weight: 229.2017096
MOL File: 66000-40-6.mol

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4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Property

Boiling point:: 308.5±52.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;25mg/ml in dimethyl formamide
form: crystalline solid
pka: 2.57±0.70(Predicted)
color: Brown to reddish brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15490
Product name: BW 755C
Purity: ≥95%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 15490
Product name: BW 755C
Purity: ≥95%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 15490
Product name: BW 755C
Purity: ≥95%
Packaging: 50mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 15490
Product name: BW 755C
Purity: ≥95%
Packaging: 100mg
Price: $595
Updated: 2024/03/01

TRC

Product number: T900553
Product name: 1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

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4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Chemical Properties,Usage,Production

Biological Activity

bw 755c is a dual inhibitor of 5-lipoxygenase (5-lo) and cyclooxygenase (cox) pathways.constitutive cyclooxygenase (cox-1) is present in cells under physiological conditions, whereas cox-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. since 5-lipoxygenase (5-lo) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid in the first step of the leukotriene pathway, 5-lo inhibitors should prevent leukotriene biosynthesis and thus prove useful in the treatment of allergic asthma.

in vitro

previous study found that bw 755c and other nonsteroidal antiinflammatory drugs including diclofenac, acetaminophen, and naproxen showed approximately equipotent inhibitory effects on cox-1 and cox-2 in intact cells. whereas, bf 389 was the most potent and most selective inhibitor of cox-2 in intact cells [1].

in vivo

an animal study was conducted to examine whether bw-755c delayed neuronal death in the hippocampal ca1 sector in mongolian gerbils after 5 minutes of forebrain ischemia. gerbils were injected with bw-755c. seven days after ischemic insult, the animals were perfusion-fixed, and the neuronal density in the hippocampal ca, sector was estimated. results showed that in ischemic gerbils with vehicle administration, the average neuronal density was 13 for bw-755c. in ischemic gerbils treated with 30 mg/kg bw-755c, the average neuronal densities was 14 [2].

IC 50

0.75 μm, 0.65 μg/ml, and 1.2 μg/ml for 5-lo, cox-1, and cox-2, respectively

References

[1] mitchell, j. a.,akarasereenont, p.,thiemermann, c., et al. selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. proceedings of the national academy of sciences of the united states of america 90, 11693-11697 (1993).
[2] nakagomi t, sasaki t, kirino t, tamura a, noguchi m, saito i, takakura k. effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. stroke. 1989 jul;20(7):925-9.

4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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66000-40-6, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amineRelated Search:

4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine

BW-755C

CGS-13592

2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine

3-amino-1-<3-(trifluoromethyl)phenyl>-2-pyrazoline

1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-

1-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-3-amine

66000-40-6