Hexamidine diisethionate

Product Name: Hexamidine diisethionate
CAS No.: 659-40-5
Chemical Name: Hexamidine diisethionate
Synonyms: SymCalmin;Desomedine;Elestab HP 100;Hexamidine 2-hydroxyethansulfonate;2535RP;HD-100;HP-100;RP-2535;Esomedina;Ophtamedine
CBNumber: CB5901139
Molecular Formula: C22H32N4O6S
Formula Weight: 480.58
MOL File: 659-40-5.mol

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Hexamidine diisethionate Property

Melting point:: 246-247° (dec)
Density: 671[at 20℃]
vapor pressure: 0Pa at 20℃
solubility: Sparingly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride
Water Solubility: 48.2g/L at 20℃
InChI: InChI=1S/C20H26N4O2.C2H6O4S/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24;3-1-2-7(4,5)6/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24);3H,1-2H2,(H,4,5,6)
InChIKey: NBVZMBLJRHUOJR-UHFFFAOYSA-N
SMILES: C(CO)S(O)(=O)=O.O(C1C=CC(C(N)=N)=CC=1)CCCCCCOC1C=CC(C(N)=N)=CC=1
LogP: 4.47 at 25℃

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Safety

RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H0330000
Product name: Hexamidine diisethionate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: h0330000
Price: $153
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: CHM0079368
Product name: 4-[6-(4-CARBAMIMIDOYLPHENOXY)HEXOXY]BENZENECARBOXIMIDAMIDE, 2-HYDROXYETHANESULFONIC ACID
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

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Hexamidine diisethionate Chemical Properties,Usage,Production

Description

Hexamidine diisethionate (HEX D) is an organic salt form of Hexamidine, which has been used as an antimicrobial agent in the personal care industry and in a variety of over-the-counter (OTC) products. For example, 0.05% HEX D solution (Keratosept?) is a new antimicrobial drop for the treatment of eye infections and is better tolerated than povidone iodine. In personal care, Hexamidine has adverse reactions such as photosensitivity and contact allergy. Therefore, the European safety assessment recommends that the content of HEX D in leave-on and rinse-off cosmetics should not exceed 0.1%^[1-2].

Chemical Properties

White or slightly yellow powder, hygroscopic

Uses

hexamidine diisethionate is an anti-microbial and preservative targeting fungi and yeast. It may also have some emollient capacities.

Uses

Hexamidinediisethionate is a preservative in topical preparations and also in skin health and personal care products.

Uses

Preservative in cosmetics.

Flammability and Explosibility

Not classified

Contact allergens

Hexamidine is an antiseptic active against Grampositive bacteria and fungi, used as a disinfectant and a preservative in cosmetics. It induces papulo-vesicular and diffuse allergic contact dermatitis.

Toxicology

Acute oral LD(50) values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hexamidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aqueous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethionate applied to 10% of the body surface of rats produced slight erythema, slight edema, and scabbing in some animals at varying times after treatment. Hexamidine Diisethionate was not a sensitizer in the guinea pig maximization test or in an intracutaneous guinea pig sensitization test. Hexamidine Diisethionate was not a photosensitizer in albino rabbits. Hexamidine Diisethionate was not mutagenic in a bacterial reverse mutagenicity assay or clastogenic in mammalian cells. Hexamidine Diisethionate at 0.10% did not provoke primary irritation, inflammation, or sensitization in a clinical test of 200 human subjects^[1].

References

[1] Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.[J]. International Journal of Toxicology, 2007, 26 Suppl 3: 79-88. DOI:10.1080/10915810701663168.
[2] F AVOGARO. Intravitreal injections primary prevention: a case-control study.[J]. European review for medical and pharmacological sciences, 2023, 27 8: 3664-3669. DOI:10.26355/eurrev\_202304\_32153.

Hexamidine diisethionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Hexamidine diisethionate Suppliers

China 294 France 3 Germany 1 India 2 United Kingdom 1 United States 5 Global 306

Cell-Free Biopharma (Shanghai) Co. , Ltd

Tel: +86-021-36696129 18016282116
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Tangshan Moneide Trading Co., Ltd.

Tel: 0315-8309571 15633399667
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Beri Pharma Co., Ltd.

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ChemFuture PharmaTech (Jiangsu) Ltd

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XiaoGan ShenYuan ChemPharm co,ltd

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View Lastest Price from Hexamidine diisethionate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Hexamidine diisethionate 659-40-5
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-13

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Hexamidine diisethionate 659-40-5
Price: US $500.00-300.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-23

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Hexamidine diisethionate 659-40-5
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

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Hexamidine 2-hydroxyethansulfonate

2-Hydroxyethanesulphonic acid,compoundwith4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine](2:1)

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2-Hydroxyethansulfonsure, Verbindung mit 4,4′-(Hexan-1,6-diylbis(oxy))bis(benzolcarboxamidin) (2:1)

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HEXAMIDINE DIISETHIONATE(HD)

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Hexamidine diisethionate, HD100,HP100

Hexamidine diisethionate Hexamidine diisethionate

Hexamidine bis (isethionate) salt

HEXAMIDINE DIISETHIONATE

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2-Hydroxyethanesulfonic acid - 4,4'-[1,6-hexanediylbis(oxy)]dibenzenecarboximidamide (1:1)

2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)

Elestab HP 100

HD-100

SymCalmin

HP-100

4'-[hexane-1

6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)

compound with 4

hexamidine disethionate

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Hexamidine isethionate

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Hexamidine diisetionate CRS

RF 2535 {Isethionate}

High Quality Hexamidine Diisethionate Powder CAS 659-40-5

4,4'-(hexane-1,6-diylbis(oxy))dibenzimidamide 2-hydroxyethanesulfonate

hexamidineisetionate

Hexamidine bis (hydroxyethyl sulfonic acid) salt

Hexamidine dihydroxyethyl sulfonate (acid value<1)

2-hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)

659-40-5

556-67-5

C20H26N4O22C2H6O4S

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