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Hexamidine diisethionate

Product Name
Hexamidine diisethionate
CAS No.
659-40-5
Chemical Name
Hexamidine diisethionate
Synonyms
SymCalmin;Desomedine;Elestab HP 100;Hexamidine 2-hydroxyethansulfonate;2535RP;HD-100;HP-100;RP-2535;Esomedina;Ophtamedine
CBNumber
CB5901139
Molecular Formula
C22H32N4O6S
Formula Weight
480.58
MOL File
659-40-5.mol
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Hexamidine diisethionate Property

Melting point:
246-247° (dec)
Density 
671[at 20℃]
vapor pressure 
0Pa at 20℃
solubility 
Sparingly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride
Water Solubility 
48.2g/L at 20℃
InChI
InChI=1S/C20H26N4O2.C2H6O4S/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24;3-1-2-7(4,5)6/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24);3H,1-2H2,(H,4,5,6)
InChIKey
NBVZMBLJRHUOJR-UHFFFAOYSA-N
SMILES
C(CO)S(O)(=O)=O.O(C1C=CC(C(N)=N)=CC=1)CCCCCCOC1C=CC(C(N)=N)=CC=1
LogP
4.47 at 25℃
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Safety

RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H0330000
Product name
Hexamidine diisethionate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
h0330000
Price
$153
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0079368
Product name
4-[6-(4-CARBAMIMIDOYLPHENOXY)HEXOXY]BENZENECARBOXIMIDAMIDE, 2-HYDROXYETHANESULFONIC ACID
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
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Hexamidine diisethionate Chemical Properties,Usage,Production

Description

Hexamidine diisethionate (HEX D) is an organic salt form of Hexamidine, which has been used as an antimicrobial agent in the personal care industry and in a variety of over-the-counter (OTC) products. For example, 0.05% HEX D solution (Keratosept?) is a new antimicrobial drop for the treatment of eye infections and is better tolerated than povidone iodine. In personal care, Hexamidine has adverse reactions such as photosensitivity and contact allergy. Therefore, the European safety assessment recommends that the content of HEX D in leave-on and rinse-off cosmetics should not exceed 0.1%[1-2].

Chemical Properties

White or slightly yellow powder, hygroscopic

Uses

hexamidine diisethionate is an anti-microbial and preservative targeting fungi and yeast. It may also have some emollient capacities.

Uses

Hexamidinediisethionate is a preservative in topical preparations and also in skin health and personal care products.

Uses

Preservative in cosmetics.

Flammability and Explosibility

Not classified

Contact allergens

Hexamidine is an antiseptic active against Grampositive bacteria and fungi, used as a disinfectant and a preservative in cosmetics. It induces papulo-vesicular and diffuse allergic contact dermatitis.

Toxicology

Acute oral LD(50) values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hexamidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aqueous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethionate applied to 10% of the body surface of rats produced slight erythema, slight edema, and scabbing in some animals at varying times after treatment. Hexamidine Diisethionate was not a sensitizer in the guinea pig maximization test or in an intracutaneous guinea pig sensitization test. Hexamidine Diisethionate was not a photosensitizer in albino rabbits. Hexamidine Diisethionate was not mutagenic in a bacterial reverse mutagenicity assay or clastogenic in mammalian cells. Hexamidine Diisethionate at 0.10% did not provoke primary irritation, inflammation, or sensitization in a clinical test of 200 human subjects[1].

References

[1] Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.[J]. International Journal of Toxicology, 2007, 26 Suppl 3: 79-88. DOI:10.1080/10915810701663168.
[2] F AVOGARO. Intravitreal injections primary prevention: a case-control study.[J]. European review for medical and pharmacological sciences, 2023, 27 8: 3664-3669. DOI:10.26355/eurrev\_202304\_32153.

Hexamidine diisethionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Hexamidine diisethionate Suppliers

China 294 France 3 Germany 1 India 2 United Kingdom 1 United States 5 Global 306
Cell-Free Biopharma (Shanghai) Co. , Ltd
Tel
+86-021-36696129 18016282116
Email
yongjian.liu@skr-cellfree.com
Country
China
ProdList
17
Advantage
58
PharmaHands (Taizhou) Co., Ltd.
Tel
0523-86200360 18994667002
Fax
0523-86200350
Email
sales@pharmahands.com.cn
Country
China
ProdList
34
Advantage
60
Hubei Qibu New Material Technology Co., Ltd.
Tel
0715-8890696 18062324989
Email
2284979616@qq.com
Country
China
ProdList
520
Advantage
58
Puripharm Co., Ltd.
Tel
0572-2745768-1 13167223168
Fax
13167223168
Email
sales@puripharm.com
Country
China
ProdList
297
Advantage
65
Tangshan Moneide Trading Co., Ltd.
Tel
0315-8309571 15633399667
Fax
+86-315-7726572
Email
sales@moneidechem.com
Country
China
ProdList
704
Advantage
57
Beri Pharma Co., Ltd.
Tel
0756-07568699456 13427714006
Fax
+86-756-8699456
Email
sales@zhberi.com
Country
China
ProdList
189
Advantage
58
Hubei xinghengkang Chemical Technology Co., Ltd
Tel
027-88878869 18162384755
Email
969094702@qq.com
Country
China
ProdList
59
Advantage
58
Shandong Suihua Biotechnology Co. Ltd
Tel
15689727968
Email
freesky2121@163.com
Country
China
ProdList
961
Advantage
58
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
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View Lastest Price from Hexamidine diisethionate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Hexamidine diisethionate 659-40-5
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-23
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Hexamidine diisethionate 659-40-5
Price
US $500.00-300.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Hexamidine diisethionate 659-40-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500KGS
Release date
2021-06-09

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