ChemicalBook > CAS DataBase List > Sisunatovir HCl
Sisunatovir HCl
- Product Name
- Sisunatovir HCl
- CAS No.
- 1903763-83-6
- Chemical Name
- Sisunatovir HCl
- Synonyms
- RV521 HCL;Sisunatovir HCl;Sisunatovir hydrochloride;Sisunatovir hydrochloride, 10 mM in DMSO;Sisunatovir hydrochloride (Synonyms: RV521 hydrochloride);1'-((5-(Aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one hydrochloride;antiviral,RV521,Inhibitor,Sisunatovir hydrochloride,syncytial,RV 521,Respiratory syncytial virus,respiratory,viral,RV-521,inhibit,RSV,Sisunatovir;Spiro[cyclopropane-1,3′-[3H]indol]-2′(1′H)-one, 1′-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzimidazol-2-yl]methyl]-6′-fluoro-, hydrochloride (1:1)
- CBNumber
- CB59023946
- Molecular Formula
- C23H23ClF4N4O
- Formula Weight
- 482.91
- MOL File
- 1903763-83-6.mol
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Sisunatovir HCl Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- Off-white to light yellow
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- 027679
- Product name
- SisunatovirHCl
- Packaging
- 001
- Price
- $950
- Updated
- 2021/12/16
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Sisunatovir HCl Chemical Properties,Usage,Production
Uses
Sisunatovir (RV521) hydrochloride is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir hydrochloride inhibits RSV infection and reduces virus titers in the lungs of mice[1].
in vivo
Sisunatovir hydrochloride (0, 1, 10, 50 mg/kg; p.o.) reduces virus titers in the lungs of mice with RSV A2 infection[1].
References
[1] DeVincenzo J, et al. A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020;64(2):e01884-19 DOI:10.1128/AAC.01884-19
Sisunatovir HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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