benzyl (S)-2,5-dioxooxazolidine-4-acetate

Product Name: benzyl (S)-2,5-dioxooxazolidine-4-acetate
CAS No.: 13590-42-6
Chemical Name: benzyl (S)-2,5-dioxooxazolidine-4-acetate
Synonyms: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate;Asp(Bzl)-NCA;Asp(Obzl)-NCA;H-ASP(OBZL)-NCA;L-Asp(Obzl)-NCA;Einecs 237-026-9;H-L-Asp(OBzl)-NCA;benzyl (S)-2,5-dioxooxazolidine-4-acetate;a-Benzyl-L-aspartic acid N-carboxyanhydride;β-Benzyl L-Aspartic Acid N-carboxyanhydride
CBNumber: CB5912917
Molecular Formula: C12H11NO5
Formula Weight: 249.22
MOL File: 13590-42-6.mol

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benzyl (S)-2,5-dioxooxazolidine-4-acetate Property

Melting point:: 120-122 °C
Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Acetone (Slightly), Chloroform (Slightly, Heated), DMSO (Slightly)
form: Solid
pka: 8.54±0.40(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: B230500
Product name: β-BenzylL-AsparticAcidN-carboxyanhydride
Packaging: 10g
Price: $185
Updated: 2021/12/16

Activate Scientific

Product number: AS93370
Product name: Benzyl (S)-2,5-Dioxooxazolidine-4-acetate
Purity: 95+% ee
Packaging: 25g
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: 4827BB
Product name: 4-Oxazolidineaceticacid,2,5-dioxo-,phenylmethylester,(S)-
Packaging: 25g
Price: $243
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 43660
Product name: β-BenzylL-asparticacidN-carboxyanhydride
Packaging: 5G
Price: $290
Updated: 2021/12/16

Crysdot

Product number: CD11279468
Product name: (S)-Benzyl2-(2,5-dioxooxazolidin-4-yl)acetate
Purity: 97%
Packaging: 5g
Price: $48
Updated: 2021/12/16

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benzyl (S)-2,5-dioxooxazolidine-4-acetate Chemical Properties,Usage,Production

Uses

β-Benzyl L-Aspartic Acid N-carboxyanhydride is used in the synthesis of PEG-poly(aspartate) block copolymer micelles in cancer cells.

Synthesis

32315-10-9

2177-63-1

13590-42-6

Under argon protection, 4.5 g of L-aspartic acid-4-benzyl ester was added to a 500 mL three-necked flask with 300 mL of freshly distilled anhydrous ethyl acetate, heated to 90 °C and refluxed for 30 min. Subsequently, 2.7 g of triphosgene was dissolved in 60 mL of freshly distilled ethyl acetate and slowly added dropwise to the reaction system through a constant pressure dropping funnel. Refluxing was maintained at 90 °C until the reaction solution became clear and transparent. Upon completion of the reaction, the reaction solution was rapidly cooled in an ice-salt bath for 30 min. The cooled reaction solution was washed sequentially with cold saturated sodium bicarbonate solution three times and cold saturated sodium chloride solution twice. The organic phase was separated and dried with anhydrous sodium sulfate for 30 minutes. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure and precipitated by the addition of freshly distilled anhydrous petroleum ether. The white solid product was collected by filtration and purified by recrystallization from ethyl acetate. White needle-like crystals were finally obtained in 83% yield.

References

[1] Journal of Drug Delivery Science and Technology, 2018, vol. 45, p. 281 - 286
[2] Patent: CN107129501, 2017, A. Location in patent: Paragraph 0012; 0013; 0014
[3] Journal of Materials Chemistry, 2012, vol. 22, # 41, p. 22290 - 22300,11
[4] Journal of Materials Chemistry, 2012, vol. 22, # 41, p. 22290 - 22300
[5] Pharmaceutical Research, 2010, vol. 27, # 11, p. 2330 - 2342

benzyl (S)-2,5-dioxooxazolidine-4-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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benzyl (S)-2,5-dioxooxazolidine-4-acetate Suppliers

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View Lastest Price from benzyl (S)-2,5-dioxooxazolidine-4-acetate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: benzyl (S)-2,5-dioxooxazolidine-4-acetate 13590-42-6
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-18

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Asp(OBzl)-NCA 13590-42-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-18

Career Henan Chemical Co

Product: benzyl (S)-2,5-dioxooxazolidine-4-acetate 13590-42-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-01

13590-42-6, benzyl (S)-2,5-dioxooxazolidine-4-acetateRelated Search:

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13590-42-6