Pyrrobutamine phosphate
- Product Name
- Pyrrobutamine phosphate
- CAS No.
- 135-31-9
- Chemical Name
- Pyrrobutamine phosphate
- Synonyms
- Einecs 205-185-3;Pyrrobutamine phosphate;Pyrrobutamine diphosphate;1-(gamma-(p-Chlorobenzyl)cinnamyl)pyrrolidine diphosphate;1-p-Chlorophenyl-2-phenyl-4-pyrrolidyl-2-butene diphosphate;1-(4-(p-Chlorophenyl)-3-phenyl-2-butenyl)pyrrolidine diphosphate;1-(4-(4-chlorophenyl)-3-phenylbut-2-enyl)pyrrolidine pentahydrogen bis(phosphate)
- CBNumber
- CB5921302
- Molecular Formula
- C20H28ClNO8P2
- Formula Weight
- 507.838742
- MOL File
- 135-31-9.mol
Pyrrobutamine phosphate Property
- Melting point:
- 129.5-130°
- pka
- pKa1 8.77, pka2 5.23(at 25℃)
Safety
- Toxicity
- LD50 in mice, guinea pigs (mg/kg): 1270 ±156, 1241 ±165 s.c.; 836.8 ±95, 625.6 ±41.9 i.m.; 1116 ±73, 992.6 ±107 orally; in mice (mg/kg): 53.53 ±1.61 i.v. (Lee)
Pyrrobutamine phosphate Chemical Properties,Usage,Production
Chemical Properties
Cream to off-white powder; slight odor; bitter taste. Melting range 127–131C. Soluble in water; slightly soluble in alcohol; almost insoluble in chloroform and ether.
Uses
Medicine (antihistamine).
brand name
Pyronil (Lilly).
General Description
Pyrrobutamine phosphate,(E)-1-[4-(4-chlorophenyl)-3-phenyl-2-butenyl]pyrrolidinediphosphate (Pyronil), is a white crystalline powder that issoluble to the extent of 10% in warm water. Pyrrobutaminewas investigated originally as the hydrochloride salt, but thediphosphate was absorbed more readily and completely.Clinical studies indicate that it is long acting, with a comparativelyslow onset of action. The weak antihistaminic propertiesof several analogs point to the importance of having aplanar ArC=CH-CH2N unit and a pyrrolidino group as theside chain tertiary amine.