ChemicalBook > CAS DataBase List > 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

Product Name
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
CAS No.
22316-55-8
Chemical Name
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
Synonyms
Clofazin;Norclobazam;Einecs 244-909-2;Demethylclobazam;Desmethylclobazam;N-Demethylclobazam;Clobazam EP Impurity A;N-Desmethylclobazam (CRM);Clobazam Related Compound A;N-Desmethylclobazam solution
CBNumber
CB5921872
Molecular Formula
C15H11ClN2O2
Formula Weight
286.71
MOL File
22316-55-8.mol
More
Less

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Property

Melting point:
>239°C (dec.)
Boiling point:
601.8±55.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
Flash point:
2℃
storage temp. 
Controlled Substance, -20°C Freezer
solubility 
Acetonitrile (Soluble)
pka
7.57±0.20(Predicted)
form 
A neat solid
More
Less

Safety

Hazard Codes 
F,Xn
Risk Statements 
11-20/21/22-36
Safety Statements 
16-36/37
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
Toxicity
mouse,LD50,oral,> 2583mg/kg (2583mg/kg),United States Patent Document. Vol. #3760074,
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D-145
Product name
N-Desmethylclobazam solution
Purity
1.0?mg/mL (acetonitrile:DMSO (90:10 v/v)), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1ML
Price
$428
Updated
2024/03/01
Sigma-Aldrich
Product number
D-049
Product name
N-Desmethylclobazam solution
Purity
100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$219
Updated
2024/03/01
Cayman Chemical
Product number
18564
Product name
N-Desmethylclobazam
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
18564
Product name
N-Desmethylclobazam
Purity
≥98%
Packaging
5mg
Price
$355
Updated
2024/03/01
Cayman Chemical
Product number
18888
Product name
N-Desmethylclobazam (CRM)
Packaging
100μg
Price
$119
Updated
2024/03/01
More
Less

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Chemical Properties,Usage,Production

Description

N-Desmethylclobazam (Item No. 18564) is an analytical reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam positively modulates GABAA receptors (EC50s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.

Description

N-Desmethylclobazam (CRM) (Item No. 18888) is a certified reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam (CRM) positively modulates GABAA receptors (EC50s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.

Chemical Properties

Off-White Solid

Uses

The major metabolite of Clobazam Controlled substance (depressant).

Definition

ChEBI: N-Desmethylclobazam is a benzodiazepine.

General Description

A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Suppliers

Canada 1 China 31 India 8 South Korea 1 United Kingdom 1 United States 3 Global 45

22316-55-8, 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dioneRelated Search:


  • 7-Chloro-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione
  • 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
  • 7-Chloro-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
  • Desmethylclobazam
  • Norclobazam
  • 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 8-chloro-1-phenyl-
  • Clofazin
  • Demethylclobazam
  • Einecs 244-909-2
  • N-Demethylclobazam
  • 8-chloro-1-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione
  • N-Desmethylclobazam solution
  • 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione
  • N-Desmethylclobazam (CRM)
  • Clobazam EP Impurity A
  • Clobazam Impurity 1（Clobazam EP Impurity A）
  • N-Desmethyl Clobazam (100 μg/mL in Acetonitrile )
  • Clobazam EP Impurity A (N-Desmethylclobazam)
  • Clobazam impurity A (Y0000241)
  • N-DesmethylclobazamQ: What is N-Desmethylclobazam Q: What is the CAS Number of N-Desmethylclobazam Q: What is the storage condition of N-Desmethylclobazam Q: What are the applications of N-Desmethylclobazam
  • Clobazam - Impurity A (Freebase)
  • Clobazam Related Compound A
  • Clobazam USP Related Compound A
  • N-Desmethylclobazam (nor-Clobazam)
  • 22316-55-8
  • 2316-55-8
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals