Nicotinamide riboside tartrate
- Product Name
- Nicotinamide riboside tartrate
- CAS No.
- 2415657-86-0
- Chemical Name
- Nicotinamide riboside tartrate
- Synonyms
- Nicotinamide riboside tartrate;Nicotinamide riboside hydrogen tartrate
- CBNumber
- CB59272942
- Molecular Formula
- C15H20N2O11
- Formula Weight
- 404.33
- MOL File
- 2415657-86-0.mol
Nicotinamide riboside tartrate Property
- InChIKey
- TXLSDIXNZRLFCH-TUYXCLBSNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O.[C@H](O)(C(=O)[O-])[C@@H](O)C(=O)O |&1:1,2,3,7,18,23,r|
Nicotinamide riboside tartrate Chemical Properties,Usage,Production
Uses
Nicotinamide riboside tartrate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
in vivo
Chronic Nicotinamide riboside tartrate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].
| Animal Model: | 10-week-old C57Bl/6J mice[1] |
| Dosage: | 400 mg/kg |
| Administration: | PO; daily; for 16 weeks |
| Result: | Increased plasma and intracellular NAD+ content in a tissue-specific manner. |
IC 50
SIRT1; SIRT3; Human Endogenous Metabolite
References
[1] Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. DOI:10.1016/j.cmet.2012.04.022
[2] Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. DOI:10.1016/j.neurobiolaging.2012.12.005
[3] Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. DOI:10.1101/2020.04.17.047480
Nicotinamide riboside tartrate Preparation Products And Raw materials
Raw materials
Preparation Products
Nicotinamide riboside tartrate Suppliers
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58