1-(4-hydroxyphenyl)-2-methoxyethan-1-one

1-(4-hydroxyphenyl)-2-methoxyethan-1-one Property

Melting point:

128-130°C

Boiling point:

315.6±22.0 °C(Predicted)

Density 

1.168±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Acetone (Slightly), Methanol (Slightly)

form 

Solid

pka

7.84±0.15(Predicted)

color 

Light Orange to Light Brown

InChI

InChI=1S/C9H10O3/c1-12-6-9(11)7-2-4-8(10)5-3-7/h2-5,10H,6H2,1H3

InChIKey

HUXGFSJRCMJOAK-UHFFFAOYSA-N

SMILES

C(=O)(C1=CC=C(O)C=C1)COC

Safety

HS Code 

2914500090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-(4-hydroxyphenyl)-2-methoxyethan-1-one Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

2-Methoxy-4''-hydroxyacetophenone (cas# 32136-81-5) is a compound useful in organic synthesis.

Preparation

Obtained by scission of 5-hydroxy-4-(4-hydroxyphenyl) 5H-furan-2-one with potassium hydroxide in methanol at 20° for 24 h (85%). – Also obtained by catalytic debenzylation of 1-(4-benzyloxyphenyl)-2-methoxyethanone in methanol under hydrogen (five bars) in the presence of 5% Pd/C for 24 h (81%).

Synthesis

General procedure for the synthesis of 1-(4-hydroxyphenyl)-2-methoxyacetophenone from 2-bromo-1-(4-hydroxyphenyl)acetophenone: Example 3 Preparation of α-methoxy-4-hydroxyacetophenone. Dissolve 2 g of α-bromo-4-hydroxyacetophenone in 11 g of methanol. 30g of methanol solution of saturated sodium hydroxide (1g NaOH dissolved in 4.2ml methanol) was slowly added dropwise to the above solution. Upon completion of the dropwise addition, the reaction mixture was poured into 30 g of ice water and the pH was adjusted with acid to 6. Subsequently, α-methoxy-4-hydroxyacetophenone precipitated as a precipitate, and after filtration and drying, a yellowish-green product was obtained in about 85% yield. The purity of the product was confirmed by 1H-NMR analysis.

References

[1] Patent: US5107034, 1992, A