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cyclobutyrol

Product Name
cyclobutyrol
CAS No.
512-16-3
Chemical Name
cyclobutyrol
Synonyms
Tribil;JL 130;Bilimix;Hebucol;Epatodin;Epadomus;Hebulina;BRN2209058;BRN 2209058;BRN-2209058
CBNumber
CB5934780
Molecular Formula
C10H18O3
Formula Weight
186.249
MOL File
512-16-3.mol
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cyclobutyrol Property

Melting point:
81-82°
Boiling point:
bp24 164°; bp16 167-170°
Density 
d418.8 1.0010
refractive index 
nD18.8 1.4680 (Kon, Naravanan, loc. cit.)
pka
4.69±0.10(Predicted)
EPA Substance Registry System
Cyclobutyrol (512-16-3)
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Safety

Toxicity
LD50 oral in rat: 4820mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0016308
Product name
CYCLOBUTYROL
Purity
95.00%
Packaging
5MG
Price
$496.79
Updated
2021/12/16
AK Scientific
Product number
4417CA
Product name
Cyclobutyrol
Packaging
500mg
Price
$791
Updated
2021/12/16
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cyclobutyrol Chemical Properties,Usage,Production

Originator

Hebucol,Logeais,France,1957

Definition

ChEBI: A hydroxy monocarboxylic acid in which the hydroxy group is geminal to a 1-carboxypropyl group on a cyclohexane ring.

Manufacturing Process

Into a balloon flask with two lateral necks furnished with an efficient mechanical agitator and protected from moisture by a calcium chloride guard, there are introduced 12 g (0.185 mol) of pure powdered zinc and 20 ml of a solution of 16.6 g (0.17 mol) of anhydrous cyclohexanone and 31.5 g (0.16 mol) of ethyl α-bromobutyrate in 25 ml of anhydrous benzene. With vigorous stirring in a manner to put the zinc into suspension, the balloon flask is gradually heated in an oil bath to 100°C to 105°C. After a few minutes, a reaction starts, causing violent boiling which is maintained while adding the balance of the reactants. Boiling is then continued for one hour. After cooling, the reaction mixture is turned into a beaker containing 30 ml of sulfuric acid to half (by volume) with ice. After agitation, the mixture is decanted into a container for separation. The aqueous phase is reextracted with benzene. The pooled benzene solutions are washed with dilute (10%) cold sulfuric acid, then with cold sodium carbonate (5%) and then with ice water, and dried over anhydrous sodium sulfate. The benzene is evaporated and the ester, which is ethyl α(hydroxy-1-cyclohexyl) butyrate, is distilled off under reduced pressure. The yield obtained was 17 to 19 g or 49% to 55%.
The ester was saponified with baryta in aqueous methanol as follows:
21.5 g (0.1 mol) of the above ethyl ester is saponified by boiling under reflux for 4 hours, while agitating, with 30 g (0.095 mol) of barium oxide hydrated to 8H2O in 250 ml of a mixture of equal volumes of methanol and water. After concentration to one-half its volume under reduced pressure and filtration, the aqueous solution is washed with ether and then acidified at 0°C with 10% hydrochloric acid. The acid liberated in oily form is extracted with ether. The ether is washed with water, dried and evaporated. The yield is 75-80% (14-15 g of crude acid) which crystallizes spontaneously little by little. It can be crystallized in a mixture of ether and petroleum ether (1:10) or, with better yield, in light gasoline or oil (solubility of the pure acid ranges from 0.3% at 0°C to 100% at the boiling point). The yield of crystals is 75-80%. The α(hydroxy-1-cyclohexyl) butyric acid thus obtained is a colorless crystalline product with a melting point of 81°C to 82°C.

Therapeutic Function

Choleretic

cyclobutyrol Preparation Products And Raw materials

Raw materials

Preparation Products

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cyclobutyrol Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
Block Chemical Technology (Shanghai) Co., LTD
Tel
021-20432219 13918097649
Fax
QQ79021576
Email
li_jinfei@acblock-lab.com
Country
China
ProdList
9964
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19711
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19863
Advantage
58

512-16-3, cyclobutyrolRelated Search:


  • cyclobutyrol
  • Bilimix
  • Epadomus
  • Epatodin
  • Hebucol
  • Hebulina
  • Tribil
  • 2-(1-hydroxycyclohexyl)butanoic acid
  • Cyclohexaneacetic acid, α-ethyl-1-hydroxy-
  • BRN 2209058
  • BRN2209058
  • BRN-2209058
  • Cyclobutyrolum
  • JL 130
  • 512-16-3