cyclobutyrol
- Product Name
- cyclobutyrol
- CAS No.
- 512-16-3
- Chemical Name
- cyclobutyrol
- Synonyms
- Tribil;JL 130;Bilimix;Hebucol;Epatodin;Epadomus;Hebulina;BRN2209058;BRN 2209058;BRN-2209058
- CBNumber
- CB5934780
- Molecular Formula
- C10H18O3
- Formula Weight
- 186.249
- MOL File
- 512-16-3.mol
cyclobutyrol Property
- Melting point:
- 81-82°
- Boiling point:
- bp24 164°; bp16 167-170°
- Density
- d418.8 1.0010
- refractive index
- nD18.8 1.4680 (Kon, Naravanan, loc. cit.)
- pka
- 4.69±0.10(Predicted)
- EPA Substance Registry System
- Cyclobutyrol (512-16-3)
Safety
- Toxicity
- LD50 oral in rat: 4820mg/kg
N-Bromosuccinimide Price
- Product number
- API0016308
- Product name
- CYCLOBUTYROL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.79
- Updated
- 2021/12/16
- Product number
- 4417CA
- Product name
- Cyclobutyrol
- Packaging
- 500mg
- Price
- $791
- Updated
- 2021/12/16
cyclobutyrol Chemical Properties,Usage,Production
Originator
Hebucol,Logeais,France,1957
Definition
ChEBI: A hydroxy monocarboxylic acid in which the hydroxy group is geminal to a 1-carboxypropyl group on a cyclohexane ring.
Manufacturing Process
Into a balloon flask with two lateral necks furnished with an efficient
mechanical agitator and protected from moisture by a calcium chloride guard,
there are introduced 12 g (0.185 mol) of pure powdered zinc and 20 ml of a
solution of 16.6 g (0.17 mol) of anhydrous cyclohexanone and 31.5 g (0.16
mol) of ethyl α-bromobutyrate in 25 ml of anhydrous benzene. With vigorous
stirring in a manner to put the zinc into suspension, the balloon flask is
gradually heated in an oil bath to 100°C to 105°C. After a few minutes, a
reaction starts, causing violent boiling which is maintained while adding the
balance of the reactants. Boiling is then continued for one hour. After cooling,
the reaction mixture is turned into a beaker containing 30 ml of sulfuric acid
to half (by volume) with ice. After agitation, the mixture is decanted into a
container for separation. The aqueous phase is reextracted with benzene. The
pooled benzene solutions are washed with dilute (10%) cold sulfuric acid, then
with cold sodium carbonate (5%) and then with ice water, and dried over
anhydrous sodium sulfate. The benzene is evaporated and the ester, which is
ethyl α(hydroxy-1-cyclohexyl) butyrate, is distilled off under reduced pressure.
The yield obtained was 17 to 19 g or 49% to 55%.
The ester was saponified with baryta in aqueous methanol as follows:
21.5 g (0.1 mol) of the above ethyl ester is saponified by boiling under reflux
for 4 hours, while agitating, with 30 g (0.095 mol) of barium oxide hydrated
to 8H2O in 250 ml of a mixture of equal volumes of methanol and water. After
concentration to one-half its volume under reduced pressure and filtration, the
aqueous solution is washed with ether and then acidified at 0°C with 10%
hydrochloric acid. The acid liberated in oily form is extracted with ether. The
ether is washed with water, dried and evaporated. The yield is 75-80% (14-15
g of crude acid) which crystallizes spontaneously little by little. It can be
crystallized in a mixture of ether and petroleum ether (1:10) or, with better
yield, in light gasoline or oil (solubility of the pure acid ranges from 0.3% at
0°C to 100% at the boiling point). The yield of crystals is 75-80%. The
α(hydroxy-1-cyclohexyl) butyric acid thus obtained is a colorless crystalline
product with a melting point of 81°C to 82°C.
Therapeutic Function
Choleretic
cyclobutyrol Preparation Products And Raw materials
Raw materials
Preparation Products
cyclobutyrol Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32063
- Advantage
- 58
- Tel
- 021-20432219 13918097649
- Fax
- QQ79021576
- li_jinfei@acblock-lab.com
- Country
- China
- ProdList
- 9964
- Advantage
- 58
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 19711
- Advantage
- 58
- Tel
- +8613564774135
- zijue.cai@tsbiochem.com
- Country
- United States
- ProdList
- 19863
- Advantage
- 58