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Rosiglitazone hydrochloride

Product Name
Rosiglitazone hydrochloride
CAS No.
302543-62-0
Chemical Name
Rosiglitazone hydrochloride
Synonyms
BRL-49653 HCl;Rosiglitazone hydroc;Rosiglitazone hydrochloride;Rosiglitazone HCl - Bio-X ?;Rosiglitazone (BRL-49653) HCl;ROSIGLITAZONE HYDROCHLORIDE 99%;Rosiglitazone hydrochloride USP/EP/BP;Rosiglitazone hydrochloride, 10 mM in DMSO;5-[4-[2-[N-Methyl-N- (pyridinyl) amino]ethoxy]benzyl]thiazol...;5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride
CBNumber
CB5947067
Molecular Formula
C18H20ClN3O3S
Formula Weight
393.89
MOL File
302543-62-0.mol
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Rosiglitazone hydrochloride Property

storage temp. 
Store at -20°C
solubility 
≥39.4 mg/mL in DMSO; ≥2.81 mg/mL in H2O with gentle warming and ultrasonic; ≥51.2 mg/mL in EtOH with ultrasonic
form 
solid
color 
White to off-white
InChI
InChI=1S/C18H19N3O3S.ClH/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;/h2-9,15H,10-12H2,1H3,(H,20,22,23);1H
InChIKey
XRSCTTPDKURIIJ-UHFFFAOYSA-N
SMILES
C(C1C=CC(OCCN(C2N=CC=CC=2)C)=CC=1)C1C(NC(=O)S1)=O.Cl
CAS DataBase Reference
302543-62-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A4310
Product name
RosiglitazoneHCl
Packaging
100mg
Price
$70
Updated
2021/12/16
ApexBio Technology
Product number
A4310
Product name
RosiglitazoneHCl
Packaging
200mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
BR164374
Product name
Rosiglitazone hydrochloride
Packaging
100mg
Price
$135
Updated
2021/12/16
ApexBio Technology
Product number
A4310
Product name
RosiglitazoneHCl
Packaging
25mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
BR164374
Product name
Rosiglitazone hydrochloride
Packaging
25mg
Price
$54
Updated
2021/12/16
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Rosiglitazone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Rosiglitazone is a hypoglycemic drug developed by GS, and the revalent compounds are disclosed in European Patent EP 306228.

Uses

Rosiglitazone hydrochloride has better stability than rosiglitazone maleate, and is very suitable for application in the manufacture of common pharmaceutical preparations. It is a thiazolidinedione antidiabetic drug, which can effectively control blood sugar by improving insulin sensitivity.

Biological Activity

rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the ppar receptors in fat cells.

in vivo

Rosiglitazone hydrochloride (oral administration, 5 mg/kg, daily for 8 weeks) decreases the serum glucose in diabetic rats[5].
Rosiglitazone hydrochloride (intraperitoneal injection, 3 mg/kg/day) ameliorates airway inflammation induced by cigarette smoke via inhibiting the M1 macrophage polarization by activating PPARγ and RXRα in male Wistar rats[6].
Rosiglitazone hydrochloride (intraperitoneal injection, 10 mg/kg, once every 2 days) inhibits subcutaneous ovarian cancer growth in A2780 and SKOV3 mouse subcutaneous xenograft models[7].

Animal Model:Streptozotocin (STZ)-induced diabetic rats[5]
Dosage:5 mg/kg
Administration:Oral administration, daily for 8 weeks.
Result:Decreased IL-6, TNF-α, and VCAM-1 levels in diabetic group.
Displayed lower levels of lipid peroxidation and NOx with an increase in aortic GSH and SOD levels compared to diabetic groups.
Animal Model:Male Wistar rats[6]
Dosage:3 mg/kg/day
Administration:Intraperitoneal injection, twice a day, 6 days per week for 12 consecutive weeks
Result:Ameliorated emphysema, elevated PEF, and higher level of total cells, neutrophils and cytokines (TNF-α and IL-1β) induced by cigarette smoke (CS).
Inhibited CS-induced M1 macrophage polarization and decreased the ratio of M1/M2.

target

TargetValue
PPAR

IC 50

PPARγ: 40 nM (Kd); PPARγ: 60 nM (EC50); TRPC5: 30 μM (EC50); TRPM3

Rosiglitazone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Rosiglitazone hydrochloride Suppliers

China 181 Germany 1 India 1 United Kingdom 2 United States 13 Global 198
Zhejiang Wansheng Pharmaceutical Co., Ltd.
Tel
0571-61102170
Email
wansheng@warm.com
Country
China
ProdList
8
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
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View Lastest Price from Rosiglitazone hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Rosiglitazone hydrochloride 302543-62-0
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-29
Baoji Guokang Healthchem co.,ltd
Product
Rosiglitazone hydrochloride 302543-62-0
Price
US $600.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10T
Release date
2021-06-03
Career Henan Chemical Co
Product
Rosiglitazone hydrochloride 302543-62-0
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

302543-62-0, Rosiglitazone hydrochlorideRelated Search:

Topotecan hydrochloride Phenetidine Pyridine hydrochloride Benzoyl peroxide 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione sodium salt Ethoxyquin Ethoxyethyne Benzyl chloride Benzyl alcohol Diethoxymethyl acetate Benzyl acetate DIETHOXYMETHANE Rosiglitazone 2-Ethoxyphenol Benzyl benzoate 2-Ethoxyethanol Rosiglitazone maleate Methyl

  • ROSIGLITAZONE HYDROCHLORIDE 99%
  • 5-[4-[2-[N-Methyl-N- (pyridinyl) amino]ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride
  • Rosiglitazone hydrochloride
  • Rosiglitazone hydroc
  • 5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride
  • 5-[(4-{2-[Methyl(pyridin-2-yl)aMino]ethoxy}phenyl)Methyl]-1,3-thiazolidine-2,4-dione hydrochloride
  • 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, hydrochloride (1:1)
  • BRL-49653 HCl
  • 2,4-Thiazolidinedione,5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-,hydrochloride
  • Rosiglitazone hydrochloride USP/EP/BP
  • 5-[4-[2-[N-Methyl-N- (pyridinyl) amino]ethoxy]benzyl]thiazol...
  • 2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-, hydrochloride (1:1)
  • Rosiglitazone (BRL-49653) HCl
  • Rosiglitazone hydrochloride, 10 mM in DMSO
  • Rosiglitazone HCl - Bio-X ?
  • 302543-62-0
  • C18H19N3O3SHCl
  • Inhibitors
  • API
  • Inhibitor