3-[(2-Pyridinyl)methylene]indolin-2-one

Product Name: 3-[(2-Pyridinyl)methylene]indolin-2-one
CAS No.: 3367-88-2
Chemical Name: 3-[(2-Pyridinyl)methylene]indolin-2-one
Synonyms: (E/Z)- SK-3inhibitor 1;(E/Z)-GSK-3inhibitor 1;(E/Z)-GSK-3β inhibitor 1;(E/Z)-GSK-3β inhibitor 1 ，E0381;3-(Pyridin-2-ylmethylene)indolin-2-one;3-[(2-Pyridinyl)methylene]indolin-2-one;(E/Z)-GSK-3β inhibitor 1, 10 mM in DMSO;3-(pyridin-2-ylmethylidene)-1H-indol-2-one;Glycogen synthase kinase 3,Inhibitor,Glycogen synthase kinase-3,inhibit,(E/Z)GSK3β inhibitor 1,GSK-3,(E/Z) GSK 3β inhibitor 1
CBNumber: CB59664651
Molecular Formula: C14H10N2O
Formula Weight: 222.25
MOL File: 3367-88-2.mol

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3-[(2-Pyridinyl)methylene]indolin-2-one Property

storage temp.: -20°C, protect from light
solubility: DMSO : 50 mg/mL (224.98 mM; Need ultrasonic)|
form: Solid
color: Orange to red
Water Solubility: Water : < 0.1 mg/mL (insoluble)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0134168
Product name: (E/Z)-GSK-3β inhibitor 1
Purity: 99.10%
Packaging: 5mg
Price: $173
Updated: 2026/06/04

ChemScene

Product number: CS-0134168
Product name: (E/Z)-GSK-3β inhibitor 1
Purity: 99.10%
Packaging: 10mg
Price: $282
Updated: 2026/06/04

ChemScene

Product number: CS-0134168
Product name: (E/Z)-GSK-3β inhibitor 1
Purity: 99.10%
Packaging: 50mg
Price: $845
Updated: 2026/06/04

ChemScene

Product number: CS-0134168
Product name: (E/Z)-GSK-3β inhibitor 1
Purity: 99.10%
Packaging: 5mg
Price: $173
Updated: 2026/06/04

ChemScene

Product number: CS-0134168
Product name: (E/Z)-GSK-3β inhibitor 1
Purity: 99.10%
Packaging: 10mg
Price: $282
Updated: 2026/06/04

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3-[(2-Pyridinyl)methylene]indolin-2-one Chemical Properties,Usage,Production

Uses

(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1].

References

[1] Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817. DOI:10.1016/j.bmc.2019.03.028

3-[(2-Pyridinyl)methylene]indolin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[(2-Pyridinyl)methylene]indolin-2-one Suppliers

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3367-88-2, 3-[(2-Pyridinyl)methylene]indolin-2-oneRelated Search:

3-[(2-Pyridinyl)methylene]indolin-2-one

(E/Z)-GSK-3inhibitor 1

(E/Z)-GSK-3β inhibitor 1

3-(Pyridin-2-ylmethylene)indolin-2-one

Glycogen synthase kinase 3,Inhibitor,Glycogen synthase kinase-3,inhibit,(E/Z)GSK3β inhibitor 1,GSK-3,(E/Z) GSK 3β inhibitor 1

(E/Z)- SK-3inhibitor 1

(E/Z)-GSK-3β inhibitor 1, 10 mM in DMSO

(E/Z)-GSK-3β inhibitor 1 ，E0381

3-(pyridin-2-ylmethylidene)-1H-indol-2-one

3367-88-2