3-[(2-Pyridinyl)methylene]indolin-2-one
- Product Name
- 3-[(2-Pyridinyl)methylene]indolin-2-one
- CAS No.
- 3367-88-2
- Chemical Name
- 3-[(2-Pyridinyl)methylene]indolin-2-one
- Synonyms
- (E/Z)- SK-3inhibitor 1;(E/Z)-GSK-3inhibitor 1;(E/Z)-GSK-3β inhibitor 1;(E/Z)-GSK-3β inhibitor 1 ，E0381;3-(Pyridin-2-ylmethylene)indolin-2-one;3-[(2-Pyridinyl)methylene]indolin-2-one;(E/Z)-GSK-3β inhibitor 1, 10 mM in DMSO;3-(pyridin-2-ylmethylidene)-1H-indol-2-one;Glycogen synthase kinase 3,Inhibitor,Glycogen synthase kinase-3,inhibit,(E/Z)GSK3β inhibitor 1,GSK-3,(E/Z) GSK 3β inhibitor 1
- CBNumber
- CB59664651
- Molecular Formula
- C14H10N2O
- Formula Weight
- 222.25
- MOL File
- 3367-88-2.mol
3-[(2-Pyridinyl)methylene]indolin-2-one Property
- storage temp.
- -20°C, protect from light
- solubility
- DMSO : 50 mg/mL (224.98 mM; Need ultrasonic)|
- form
- Solid
- color
- Orange to red
- Water Solubility
- Water : < 0.1 mg/mL (insoluble)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
3-[(2-Pyridinyl)methylene]indolin-2-one Chemical Properties,Usage,Production
Uses
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1].
References
[1] Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817. DOI:10.1016/j.bmc.2019.03.028
3-[(2-Pyridinyl)methylene]indolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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