SB269970 HCl

ChemicalBook > CAS DataBase List > SB269970 HCl

Product Name: SB269970 HCl
CAS No.: 261901-57-9
Chemical Name: SB269970 HCl
Synonyms: SB-269970A;SB269970 HCl USP/EP/BP;SB269970 HClSB269970 HCl;SB-269970A|||SB269970 HCl;SB269970 HCl (SB-269970A);SB269970 hydrochloride, >=98%;SB 269970 hydrochloride, 5-HT7 receptor antagonist;(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1)
CBNumber: CB5972915
Molecular Formula: C18H28N2O3SHCl
Formula Weight: 0
MOL File: 261901-57-9.mol

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SB269970 HCl Property

storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL, clear (warmed to 60 °C)
form: powder
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7389
Product name: SB-269970 hydrochloride
Purity: powder, ≥98% (HPLC)
Packaging: 5mg
Price: $353
Updated: 2024/03/01

Sigma-Aldrich

Product number: S7389
Product name: SB-269970 hydrochloride
Purity: powder, ≥98% (HPLC)
Packaging: 25mg
Price: $1230
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.06415
Product name: SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem
Packaging: 10MG
Price: $196
Updated: 2023/06/20

Cayman Chemical

Product number: 17081
Product name: SB-269970 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 17081
Product name: SB-269970 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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SB269970 HCl Chemical Properties,Usage,Production

Description

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT_7A antagonist (pK_i = 8.9) that demonstrates >50-fold binding selectivity over 5-HT_5A and >250-fold selectivity over 5-HT₁, 5-HT₂, 5-HT₄, 5-HT₆, adrenergic α₁, dopamine D₂, and dopamine D₃ receptors. It is also reported to block adrenergic α₂ receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT₇ receptor in the study of schizophrenia-like cognitive deficits.

Uses

SB 269970A is a selective 5-HT7 receptor antagonist.

General Description

A selective 5-HT₇ receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT₇ receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT₇ antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT_5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT_7A, 5-HT_5A and 5-HT_1B).

Biochem/physiol Actions

Primary Target5-HT

storage

+4°C

References

[1] hagan j j, price g w, jeffrey p, et al. characterization of sb-269970-a, a selective 5-ht7 receptor antagonist. british journal of pharmacology, 2000, 130(3): 539-548.

SB269970 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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SB269970 HCl Suppliers

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261901-57-9, SB269970 HClRelated Search:

SB-269970A

(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride

(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride

SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride

(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride

Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1)

SB269970 hydrochloride, >=98%

SB269970 HClSB269970 HCl

SB269970 HCl USP/EP/BP

SB269970 HCl (SB-269970A)

SB-269970A|||SB269970 HCl

SB 269970 hydrochloride, 5-HT7 receptor antagonist

261901-57-9

C18H28N2O3SHCl

Inhibitors