ChemicalBook > CAS DataBase List > SB269970 HCl

SB269970 HCl

Product Name
SB269970 HCl
CAS No.
261901-57-9
Chemical Name
SB269970 HCl
Synonyms
SB-269970A;SB269970 HCl USP/EP/BP;SB269970 HClSB269970 HCl;SB269970 HCl (SB-269970A);SB269970 hydrochloride, >=98%;(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1);(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride;SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
CBNumber
CB5972915
Molecular Formula
C18H28N2O3SHCl
Formula Weight
0
MOL File
261901-57-9.mol
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SB269970 HCl Property

storage temp. 
2-8°C
solubility 
H2O: soluble10mg/mL, clear (warmed to 60 °C)
form 
powder
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7389
Product name
SB-269970 hydrochloride
Purity
powder, ≥98% (HPLC)
Packaging
5mg
Price
$353
Updated
2024/03/01
Sigma-Aldrich
Product number
S7389
Product name
SB-269970 hydrochloride
Purity
powder, ≥98% (HPLC)
Packaging
25mg
Price
$1230
Updated
2024/03/01
Sigma-Aldrich
Product number
5.06415
Product name
SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem
Packaging
10MG
Price
$196
Updated
2023/06/20
Cayman Chemical
Product number
17081
Product name
SB-269970 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
17081
Product name
SB-269970 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
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SB269970 HCl Chemical Properties,Usage,Production

Description

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.

Uses

SB 269970A is a selective 5-HT7 receptor antagonist.

General Description

A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).

Biochem/physiol Actions

Primary Target5-HT

storage

+4°C

References

[1] hagan j j, price g w, jeffrey p, et al. characterization of sb-269970-a, a selective 5-ht7 receptor antagonist. british journal of pharmacology, 2000, 130(3): 539-548.

SB269970 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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261901-57-9, SB269970 HClRelated Search:


  • SB-269970A
  • (R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride
  • (r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
  • SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
  • (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride
  • Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1)
  • SB269970 hydrochloride, >=98%
  • SB269970 HClSB269970 HCl
  • SB269970 HCl USP/EP/BP
  • SB269970 HCl (SB-269970A)
  • 261901-57-9
  • C18H28N2O3SHCl
  • Inhibitors