PD-118057

Product Name: PD-118057
CAS No.: 313674-97-4
Chemical Name: PD-118057
Synonyms: PD118057,PD 118057;PD-118057, 10 mM in DMSO;PD-118057 >=98% (HPLC), solid;2-((4-(3,4-Dichlorophenethyl)phenyl)amino)benzoic acid;Benzoic acid, 2-[[4-[2-(3,4-dichlorophenyl)ethyl]phenyl]amino]-
CBNumber: CB5972975
Molecular Formula: C21H17Cl2NO2
Formula Weight: 386.27
MOL File: 313674-97-4.mol

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PD-118057 Property

Boiling point:: 527.0±50.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble9mg/mL
pka: 3.70±0.36(Predicted)
form: solid
color: light yellow
InChI: InChI=1S/C21H17Cl2NO2/c22-18-12-9-15(13-19(18)23)6-5-14-7-10-16(11-8-14)24-20-4-2-1-3-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)
InChIKey: ZCQOSCDABPVAFB-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=CC=C1NC1=CC=C(CCC2=CC=C(Cl)C(Cl)=C2)C=C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P5624
Product name: PD-118057
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $227
Updated: 2025/07/31

Sigma-Aldrich

Product number: P5624
Product name: PD-118057
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $594
Updated: 2025/07/31

TRC

Product number: P218358
Product name: PD118057
Packaging: 1mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0029270
Product name: PD-118057
Purity: >99.0%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008379
Product name: PD-118057
Purity: 95.00%
Packaging: 10MG
Price: $665.44
Updated: 2021/12/16

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PD-118057 Chemical Properties,Usage,Production

Uses

PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability[1][2].

Biological Activity

PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure

References

[1] Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8(6):e65481. DOI:10.1371/journal.pone.0065481
[2] Yeung SY, et al. Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am J Physiol Cell Physiol. 2007 Jan;292(1):C468-76. DOI:10.1152/ajpcell.00142.2006
[3] Meng J, et al. Effect of PD-118057attenuates hypokalaemia or drug-induced prolongation of action potential duration in guinea pig ventricular myocytes. 2014,29(05):536-538.

PD-118057 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD-118057 Suppliers

China 25 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 34

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Jinan Jiuli Biotechnology Co. , Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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313674-97-4, PD-118057Related Search:

Benzoic acid, 2-[[4-[2-(3,4-dichlorophenyl)ethyl]phenyl]amino]-

PD-118057 >=98% (HPLC), solid

PD118057,PD 118057

2-((4-(3,4-Dichlorophenethyl)phenyl)amino)benzoic acid

PD-118057, 10 mM in DMSO

313674-97-4