ChemicalBook > CAS DataBase List > 2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-

2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-

Product Name
2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-
CAS No.
2607829-38-7
Chemical Name
2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-
Synonyms
BDTX-1535;Silevertinib;"(2E)-N-[4-[(3-Chloro-2-fluorophenyl)amino]-7-[2- [(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-2-b";(E)-N-(4-((3-Chloro-2-fluorophenyl)amino)-7-(((1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl)ethynyl)quinazolin-6-yl)-4-morpholinobut-2-enamide;2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-
CBNumber
CB59776602
Molecular Formula
C30H30ClFN6O2
Formula Weight
561.05
MOL File
2607829-38-7.mol
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2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)- Property

Boiling point:
730.0±60.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
pka
11.44±0.43(Predicted)
form 
Solid
color 
Light yellow to yellow
InChIKey
LMOVDLRMIRLIJF-TUVXKDNKSA-N
SMILES
C(NC1C(C#C[C@]23[C@]([H])(C2)CN(C)C3)=CC2C(C=1)=C(NC1=CC=CC(Cl)=C1F)N=CN=2)(=O)/C=C/CN1CCOCC1
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Hazard and Precautionary Statements (GHS)

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2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)- Chemical Properties,Usage,Production

Uses

BDTX-1535 (EGFR-IN-76, compound 37A) is an orally active, brain-penetrant, selective and potent EGFR tyrosine kinase inhibitor. BDTX-1535 achieves potent anti-tumor activity against EGFR alterations and amplification across models including NSCLC, GBM PDX and intracranial tumors[1][2][3].

References

[1] Lucas MC, et al. Preparation of alkynyl quinazoline compounds as anticancer agents. World Intellectual Property Organization, WO2021030711 A1. 2021-02-18.
[2] O'Connor M, et al. Discovery of BDTX-1535, a novel 4th generation, irreversible, potent, wild type sparing EGFR MasterKey inhibitor that targets oncogenic kinase domain mutations as well as extracellular domain alterations for the treatment of NSCLC and GBM[J]. Cancer Research, 2023, 83(7_Supplement): 3396-3396.
[3] Lucas M, et al. BDTX-1535, a fourth generation EGFR inhibitor, targeting intrinsic and acquired resistance mutations in NSCLC[J]. European Journal of Cancer, 2022, 174: S22.

2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)- Suppliers

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Anqing Benro pharmachem Technology Co.,Ltd.
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2607829-38-7, 2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-Related Search:


  • 2-Butenamide, N-[4-[(3-chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-, (2E)-
  • BDTX-1535
  • (E)-N-(4-((3-Chloro-2-fluorophenyl)amino)-7-(((1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl)ethynyl)quinazolin-6-yl)-4-morpholinobut-2-enamide
  • Silevertinib
  • "(2E)-N-[4-[(3-Chloro-2-fluorophenyl)amino]-7-[2- [(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-2-b"
  • 2607829-38-7
  • C30H30ClFN6O2