ChemicalBook > CAS DataBase List > E-7820

E-7820

Product Name: E-7820
CAS No.: 289483-69-8
Chemical Name: E-7820
Synonyms: E-7820;CS-2701;ER 68203-00;E 7820; E-7820;E7820, 10 mM in DMSO;ER68203-00;E7820;E-7820;E 7820;289483-69-8;3-Cyano-N-(3-cyano-4-methyl-7-indolyl)benzenesulfonamide;3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide;N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide;Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-
CBNumber: CB61011214
Molecular Formula: C17H12N4O2S
Formula Weight: 336.37
MOL File: 289483-69-8.mol

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E-7820 Property

Boiling point:: 626.2±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:67.0(Max Conc. mg/mL);199.19(Max Conc. mM)
form: A crystalline solid
pka: 8.17±0.30(Predicted)
color: Light yellow to light brown
InChI: InChI=1S/C17H12N4O2S/c1-11-5-6-15(17-16(11)13(9-19)10-20-17)21-24(22,23)14-4-2-3-12(7-14)8-18/h2-7,10,20-21H,1H3
InChIKey: LWGUASZLXHYWIV-UHFFFAOYSA-N
SMILES: C1(S(NC2C3=C(C(C)=CC=2)C(C#N)=CN3)(=O)=O)=CC=CC(C#N)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2950
Product name: E7820
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $77.77
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2950
Product name: E7820
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $268
Updated: 2025/07/31

Cayman Chemical

Product number: 25502
Product name: E7820
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 25502
Product name: E7820
Purity: ≥98%
Packaging: 10mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 25502
Product name: E7820
Purity: ≥98%
Packaging: 50mg
Price: $283
Updated: 2024/03/01

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E-7820 Chemical Properties,Usage,Production

Description

E7820 is a sulfonamide derivative and an angiogenesis inhibitor that inhibits bFGF- and VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation (IC₅₀s = 0.1 and 0.081 μg/ml, respectively). It inhibits bFGF- and VEGF-stimulated tube formation of HUVECs in a concentration-dependent manner (IC₅₀s = 0.2 and 0.24 μg/ml, respectively). E7820 selectively decreases the surface expression and mRNA levels of integrin α2 over CD31 and VE-cadherin in HUVECs. In vivo, E7820 (200 and 400 mg/kg) reduces tumor growth and inhibits angiogenesis in a WiDr colorectal cancer mouse xenograft model. It also reduces tumor weight in a panel of seven human colon, breast, pancreas, and kidney cancer mouse xenograft models, completely inhibits tumor growth in KP-1 pancreatic and LoVo colon cancer mouse xenograft models, and inhibits tumor growth in KP-1 and COLO 320DM mouse orthotopic transplantation models.

Uses

E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. Antiangiogenic and antitumor activity[1][2].

reaction suitability

reagent type: ligand

in vivo

E7820 (ER68203-00) (50-200 mg/kg; p.o. ; twice daily for 14 days) delays the growth of WiDr cells inoculated s.c.^[1].
E7820 (200-400 mg/kg; p.o.;once daily for 4 days) potently inhibits WiDr-induced angiogenesis^[1].

Animal Model:	Six-week-old female nude mice (KSN mice, WiDr-induced angiogenesis model) ^[1]
Dosage:	50, 100, 200 mg/kg
Administration:	p.o. ; twice daily for 14 days from 2 days after inoculation of the tumor cells
Result:	The antitumor effect was dose-dependent at 50, 100, and 200 mg/kg, and the tumor growth rates were 52%, 46%, and 27%, respectively.

storage

Store at -20°C

References

[1] Funahashi Y, et al. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Cancer Res. 2002;62(21):6116-6123. PMID:12414636
[2] Ito K, et al. Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. Cancer Sci. 2014;105(8):1023-1031. DOI:10.1111/cas.12450

E-7820 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-7820 Suppliers

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289483-69-8, E-7820Related Search:

E-7820

ER 68203-00

3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide

N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide

E 7820; E-7820

CS-2701

ER68203-00;E7820;E-7820;E 7820;289483-69-8

Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-

E7820,cell,tumor,WiDr,derivative,Integrin,colorectal,LoVo,inhibit,Inhibitor,sulfonamide,HUVEC,endothelium,E 7820,E-7820

3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239

E7820, 10 mM in DMSO

3-Cyano-N-(3-cyano-4-methyl-7-indolyl)benzenesulfonamide

289483-69-8