2-Fluoro-4-Bromo-3-Picoline
- Product Name
- 2-Fluoro-4-Bromo-3-Picoline
- CAS No.
- 128071-79-4
- Chemical Name
- 2-Fluoro-4-Bromo-3-Picoline
- Synonyms
- 2-Fluoro-4-Bromo-3-Picoline;4-BROMO-2-FLUORO-3-METHYLPYRIDIN;4-Bromo-2-fluoro-3-methylpyridine;2-Fluoro-4-bromo-3-methylpyridine;bromo-4 fluoro-2 methyl-3 pyridine;Pyridine, 4-bromo-2-fluoro-3-methyl-;2-Fluoro-4-Bromo-3-Picoline ISO 9001：2015 REACH
- CBNumber
- CB61032949
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 128071-79-4.mol
2-Fluoro-4-Bromo-3-Picoline Property
- Boiling point:
- 220℃
- Density
- 1.592
- Flash point:
- 87℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 1.05±0.10(Predicted)
- form
- Oil
- color
- Colourless
Safety
- RIDADR
- UN1993
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B568580
- Product name
- 4-Bromo-2-fluoro-3-methylpyridine
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FB43529
- Product name
- 4-Bromo-2-fluoro-3-methylpyridine
- Packaging
- 500mg
- Price
- $415
- Updated
- 2021/12/16
- Product number
- FB43529
- Product name
- 4-Bromo-2-fluoro-3-methylpyridine
- Packaging
- 250mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- PC445018
- Product name
- 4-Bromo-2-fluoro-3-methylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 3H32-B-0Q
- Product name
- 4-Bromo-2-fluoro-3-methylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
2-Fluoro-4-Bromo-3-Picoline Chemical Properties,Usage,Production
Uses
2-Fluoro-4-bromo-3-pyridine is an organic compound that is often used as an intermediate in chemical synthesis, especially in the synthesis of drugs and pesticides.
Synthesis
128071-98-7
74-88-4
128071-79-4
A solution of lithium diisopropylammonium (LDA, 2M, 8.5 mL) was added slowly and dropwise to a solution of 4-bromo-2-fluoropyridine (2 g, 11.3 mmol) in tetrahydrofuran (THF, 40 mL) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 1 h, followed by dropwise addition of iodomethane (4.8 g, 34 mmol). After continued stirring at -78 °C for 1 h, the reaction mixture was allowed to slowly warm up to room temperature over a period of 1 h. The reaction was completed with the addition of iodomethane (4.8 g, 34 mmol). Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution, followed by the addition of an aqueous solution of ammonium chloride (NH4Cl, 50 mL) at 0 °C and extraction with ethyl acetate (EA, 60 mL x 3). The organic layers were combined, washed with brine (60 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, PE/EtOAc) to afford 2-fluoro-3-methyl-4-bromopyridine (1 g, 47% yield) as a yellow solid.1H-NMR (400 MHz, CDCl3) δppm: 2.35 (s, 3H), 7.36 (d, 1H), 7.86 (d, 1H).
References
[1] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00188
2-Fluoro-4-Bromo-3-Picoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-Bromo-3-Picoline manufacturers
- Product
- 2-Fluoro-4-Bromo-3-Picoline 128071-79-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-31