ChemicalBook > CAS DataBase List > Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
- Product Name
- Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
- CAS No.
- 126069-70-3
- Chemical Name
- Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)
- Synonyms
- 8-METHYL-2-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRAZINE;2-(trifluoroMethyl)-5H,6H,7H,8H-iMidazo[1,2-a]pyrazine;2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE;5,6,7,8-Tetrahydro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine;IMidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoroMethyl)-;2-(TrifluoroMethyl)-5,6,7,8-tetrahydroiMidazo[1,2-a]pyrazine HCl;2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 2HCl;Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI);2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride
- CBNumber
- CB61043282
- Molecular Formula
- C7H8F3N3
- Formula Weight
- 191.15
- MOL File
- 126069-70-3.mol
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Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) Property
- Boiling point:
- 313.0±42.0 °C(Predicted)
- Density
- 1.56
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.90±0.20(Predicted)
- Appearance
- Off-white to light brown Solid
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- MNO000185
- Product name
- 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
- Packaging
- 1g
- Price
- $201
- Updated
- 2023/01/07
TRC
- Product number
- T797168
- Product name
- 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
- Packaging
- 1g
- Price
- $310
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC520909
- Product name
- 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
- Purity
- 95%
- Packaging
- 5g
- Price
- $434
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H31-3-7E
- Product name
- 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
- Purity
- 95%
- Packaging
- 5G
- Price
- $695
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0049752
- Product name
- 2-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $756.53
- Updated
- 2021/12/16
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Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) Chemical Properties,Usage,Production
Uses
2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine is used to study fused heterocycle-linked triazole derivatives.
Synthesis
109113-96-4
126069-70-3
The general procedure for the synthesis of 2-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine using 2-trifluoromethylimidazo[1,2-a]pyrazine as a starting material was as follows: 2-trifluoromethylimidazo[1,2-a]pyrazine (2.40 g, 12.55 mmol) was dissolved in methanol (100 mL) with 10% Pd/C catalyst (480 mg ). The reaction system was displaced three times with hydrogen to ensure an oxygen-free environment. After stirring the reaction for 12 h at room temperature, the catalyst was removed by filtration and the filter cake was washed with methanol. The filtrates were combined and concentrated under reduced pressure to afford 2-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (2.30 g, 95.8% yield) as a yellow oil.
References
[1] Patent: EP2604610, 2013, A1. Location in patent: Paragraph 0114; 0116
[2] Patent: US2013/131068, 2013, A1. Location in patent: Paragraph 0165
[3] Patent: WO2010/125101, 2010, A1. Location in patent: Page/Page column 51-52
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 9, p. 3687 - 3706
[5] Patent: WO2006/9886, 2006, A1. Location in patent: Page/Page column 43
Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) manufacturers
Career Henan Chemical Co
- Product
- Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI) 126069-70-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09
126069-70-3, Imidazo[1,2-a]pyrazine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)- (9CI)Related Search:
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