4-(BROMOMETHYL)-3-NITROBENZOIC ACID

4-(BROMOMETHYL)-3-NITROBENZOIC ACID Property

Melting point:

45-47 °C(lit.)

Boiling point:

277.8±25.0 °C(Predicted)

Density 

1.813±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

solid

Safety

Hazard Codes 

C,Xn

Risk Statements 

34-43-36-22

Safety Statements 

26-36/37/39-45-36/37

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

19

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-(BROMOMETHYL)-3-NITROBENZOIC ACID Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 2-(bromomethyl)-5-nitrofuran from (5-nitrofuran-2-yl)methanol: tribromoisocyanuric acid (14.05 g, 38.34 mmol, 1.5 eq.) was added to a stirred solution of triphenylphosphine (39.40 g, 150.24 mmol, 4.3 eq.) in dichloromethane (200 mL). after 30 min. (5-nitrofuran-2-yl)methanol (5 g, 34.94 mmol, 1 eq.) was added and the suspension was stirred at room temperature for 4 hours. After completion of the reaction, the precipitated cyanuric acid was filtered out and the organic layer was washed with water (4 x 100 mL), followed by brine solution. The organic layer was dried with Na2SO4, filtered and evaporated under reduced pressure. The residue obtained was treated with hexane and filtered through a short column filled with silica gel (100-200 mesh). Evaporation of hexane afforded the target product 2-(bromomethyl)-5-nitrofuran as a yellow oily liquid; Yield: 6.33 g, 84%. IR (KBr, νmax, cm-1 ): 1526 and 1345 (NO2); 1H NMR (400 MHz, CDCl3) δ 4.49 (s, 2H), 6.64 (d, J = 4.0 Hz. 1H, H3-furan), 7.28 (d, J = 4.0 Hz, 1H, H4-furan).

References

[1] Asian Journal of Chemistry, 2018, vol. 30, # 2, p. 312 - 316
[2] Patent: WO2017/17631, 2017, A2. Location in patent: Paragraph 00310
[3] Medicinal Chemistry Research, 2013, vol. 22, # 12, p. 5940 - 5947