Ethanone, 1-[2-(methylamino)phenyl]- (9CI)
- Product Name
- Ethanone, 1-[2-(methylamino)phenyl]- (9CI)
- CAS No.
- 1859-75-2
- Chemical Name
- Ethanone, 1-[2-(methylamino)phenyl]- (9CI)
- Synonyms
- 1-(2-MethylaMino-phenyl)-ethanone;Ethanone, 1-[2-(methylamino)phenyl]-;Ethanone, 1-[2-(methylamino)phenyl]- (9CI)
- CBNumber
- CB61063617
- Molecular Formula
- C9H11NO
- Formula Weight
- 149.19
- MOL File
- 1859-75-2.mol
Ethanone, 1-[2-(methylamino)phenyl]- (9CI) Property
- Melting point:
- 33-33.5 °C
- Boiling point:
- 117-118 °C(Press: 11 Torr)
- Density
- 1.062±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.88±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2922390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M288330
- Product name
- 1-(2-methylamino-phenyl)-ethanone
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CHM0386694
- Product name
- 1-(2-(METHYLAMINO)PHENYL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.42
- Updated
- 2021/12/16
- Product number
- A127363
- Product name
- 1-(2-(Methylamino)phenyl)ethanone
- Purity
- 95%
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CC00-1971
- Product name
- 1-(2-Methylamino-phenyl)-ethanone
- Purity
- ＞95%
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- A127363
- Product name
- 1-(2-(Methylamino)phenyl)ethanone
- Purity
- 95%
- Packaging
- 1g
- Price
- $244
- Updated
- 2021/12/16
Ethanone, 1-[2-(methylamino)phenyl]- (9CI) Chemical Properties,Usage,Production
Synthesis
551-93-9
74-88-4
1859-75-2
To an oven-dried round-bottomed flask containing K2CO3 (3.46 g, 25 mmol, 1 equiv) suspended in anhydrous DMF (15 mL) was added 1-(2-aminophenyl)ethan-1-one (3.04 mL, 25 mmol). The reaction mixture was stirred at room temperature for 15 minutes under argon protection. Subsequently, anhydrous DMF solution of MeI (1.56 mL, 25 mmol, 1 equiv) was added slowly and dropwise to the reaction mixture. Stirring of the reaction mixture was continued at room temperature for 3 days. Upon completion of the reaction, the reaction mixture was diluted with H2O (60 mL) and extracted with ethyl acetate (340 mL). The organic phases were combined, washed sequentially with water (50 mL) and brine (50 mL) and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuum and purified by column chromatography (3%-5% petroleum ether solution of ethyl acetate) to afford 1-(2-(methylamino)phenyl)ethan-1-one (1.98 g, 53%) as yellow crystals. Next, 1-(bromomethyl)-2-iodobenzene (1.48 g, 5 mmol), 1-(2-(methylamino)phenyl)ethan-1-one (895 mg, 6 mmol, 1.1 eq.), K2CO3 (1.38 g, 10 mmol, 2 eq.), and acetonitrile (5 mL) were added to an oven-dried, high-pressure sealed tube. The reaction mixture was stirred at 85 °C for 4 days. After completion of the reaction, it was cooled to room temperature, diluted with H2O (20 mL) and extracted with dichloromethane (315 mL). The organic phases were combined, washed with brine (40 mL) and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuum and purified by column chromatography (petroleum ether solution of 5% ethyl acetate) to afford 1-(2-((2-iodobenzyl)(methyl)amino)phenyl)ethan-1-one (1.45 g, 79%) as orange crystals.
References
[1] Liebigs Annalen der Chemie, 1990, # 8, p. 795 - 805
[2] Tetrahedron, 2016, vol. 72, # 48, p. 7875 - 7887
[3] Journal of Organic Chemistry, 2011, vol. 76, # 8, p. 2635 - 2647
[4] RSC Advances, 2016, vol. 6, # 70, p. 65988 - 65994
[5] Advanced Synthesis and Catalysis, 2014, vol. 356, # 2-3, p. 353 - 358
Ethanone, 1-[2-(methylamino)phenyl]- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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