4-(2-Hydroxyethyl)benzaldehyde
- Product Name
- 4-(2-Hydroxyethyl)benzaldehyde
- CAS No.
- 163164-47-4
- Chemical Name
- 4-(2-Hydroxyethyl)benzaldehyde
- Synonyms
- 4-(2-Hydroxyethyl)benzaldehyde;Benzaldehyde, 4-(2-hydroxyethyl)-;4-(2-Hydroxyethyl)phenylcarboxaldehyde;Benzaldehyde, 4-(2-hydroxyethyl)- (9CI)
- CBNumber
- CB61066188
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 163164-47-4.mol
4-(2-Hydroxyethyl)benzaldehyde Property
- Boiling point:
- 295℃
- Density
- 1.142
- Flash point:
- 124℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Oil
- pka
- 14.72±0.10(Predicted)
- color
- Colourless
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H827400
- Product name
- 4-(2-Hydroxyethyl)benzaldehyde
- Packaging
- 5g
- Price
- $1390
- Updated
- 2021/12/16
- Product number
- CHM0150268
- Product name
- 4-(2-HYDROXYETHYL)BENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2136.75
- Updated
- 2021/12/16
- Product number
- 8288AA
- Product name
- 4-(2-Hydroxyethyl)benzaldehyde
- Packaging
- 1g
- Price
- $562
- Updated
- 2021/12/16
- Product number
- CHM0150268
- Product name
- 4-(2-HYDROXYETHYL)BENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- 8288AA
- Product name
- 4-(2-Hydroxyethyl)benzaldehyde
- Packaging
- 100mg
- Price
- $178
- Updated
- 2021/12/16
4-(2-Hydroxyethyl)benzaldehyde Chemical Properties,Usage,Production
Uses
4-(2-Hydroxyethyl)benzaldehyde is used in the synthesis of thromboxane receptor antagonists and -thromboxane synthase inhibitors based on a dioxane linkage.
Synthesis
163164-46-3
163164-47-4
General procedure for the synthesis of 4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzaldehyde from 4-(2-hydroxyethyl)benzaldehyde: 1. 2.8 g (11.95 mmol) of 4-[2-(tetrahydropyran-2-yloxy)-ethyl]-benzaldehyde was dissolved in a mixture of 48 mL of 1 M hydrochloric acid and 60 mL of acetone, and the reaction was stirred for 5 hr at 5 °C. 2. Upon completion of the reaction, the reaction mixture was combined with 140 mL of saturated sodium bicarbonate solution and extracted with ethyl acetate. 3. The organic phases were combined, washed three times with water and then dried over anhydrous sodium sulfate. 4. Purification was carried out by silica gel column chromatography with the eluent cyclohexane/ethyl acetate (1:1). 5. The product 4-(2-hydroxyethyl)benzaldehyde was obtained as 1.3 g in 72.4% yield. Product characterization: C9H10O2 (M = 150.17); calculated value: molar peak (M + H)+: 151; measured value: molar peak (M + H)+: 151; Rf value: 0.52 (silica gel, petroleum ether/ethyl acetate 1:1).
References
[1] Patent: US2004/242572, 2004, A1. Location in patent: Page/Page column 52
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 10, p. 1608 - 1628
4-(2-Hydroxyethyl)benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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