2-Fluoro-3-methoxyaniline
- Product Name
- 2-Fluoro-3-methoxyaniline
- CAS No.
- 801282-00-8
- Chemical Name
- 2-Fluoro-3-methoxyaniline
- Synonyms
- 3-Amino-2-fluoroanisole;2-Fluoro-3-methoxyaniline;2-fluoro-3-methoxybenzenamine;2-Fluoro-3-Methoxy-phenylaMine;Benzenamine, 2-fluoro-3-methoxy-;Benzenamine, 2-fluoro-3-methoxy- (9CI);Benzenamine, 2-fluoro-3-methoxy-, hydrochloride;3-AMino-2-fluoroanisole[2-Fluoro-3-Methoxyaniline]
- CBNumber
- CB61067660
- Molecular Formula
- C7H8FNO
- Formula Weight
- 141.14
- MOL File
- 801282-00-8.mol
2-Fluoro-3-methoxyaniline Property
- Boiling point:
- 231℃
- Density
- 1.176
- Flash point:
- 94℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- liquid
- pka
- 2.78±0.10(Predicted)
- color
- Light brown to brown
- InChI
- InChI=1S/C7H8FNO/c1-10-6-4-2-3-5(9)7(6)8/h2-4H,9H2,1H3
- InChIKey
- KOSZHDVTNURERE-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC(OC)=C1F
Safety
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F593305
- Product name
- 2-Fluoro-3-methoxyaniline
- Packaging
- 250mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- FB32221
- Product name
- Benzenamine,2-fluoro-3-methoxy-(9CI)
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB32221
- Product name
- Benzenamine,2-fluoro-3-methoxy-(9CI)
- Packaging
- 1g
- Price
- $62.5
- Updated
- 2021/12/16
- Product number
- FB32221
- Product name
- Benzenamine,2-fluoro-3-methoxy-(9CI)
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- W8530
- Product name
- 2-FLUORO-3-METHOXYANILINE
- Packaging
- 1g
- Price
- $134
- Updated
- 2021/12/16
2-Fluoro-3-methoxyaniline Chemical Properties,Usage,Production
Uses
2-Fluoro-3-methoxyaniline is a reagent that is used in the structure-activity relationship studies on a series of cyclopentane-containing macrocyclic inhibitors of hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Synthesis
137654-20-7
801282-00-8
General procedure for the synthesis of 2-fluoro-3-methoxyaniline from 2-fluoro-3-methoxybenzoic acid: To a solution of 2-fluoro-3-methoxybenzoic acid (15.0 g, 88 mmol) and triethylamine (13.49 mL, 96.8 mmol) in toluene (300 mL) was added diphenylphosphoryl azide (20.9 mL, 96.8 mmol). The reaction mixture was heated to reflux for 1 hour. Subsequently, 2-methyl-2-propanol (12.5 mL, 132 mmol) was added and refluxing was continued for 5 hours. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The organic phase was separated by partitioning the residue between water and dichloromethane. The organic phase was dried with anhydrous sodium sulfate, filtered and passed through a short column of 1 inch silica gel and concentrated again. The resulting residue was dissolved in dichloromethane (200 mL), trifluoroacetic acid (25 mL) was added and stirred at room temperature overnight. Upon completion of the reaction, it was concentrated under reduced pressure and the residue partitioned between dichloromethane and saturated sodium bicarbonate solution. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. Finally, purification by silica gel column chromatography (eluent: isohexane solution containing 15% ethyl acetate) afforded the target product 2-fluoro-3-methoxyaniline as a light yellow oil (10.8 g, 87% yield).1H NMR (400 MHz, CDCl3) δ 3.72 (2H, br s), 3.85 (3H, s), 6.34-6.41 (2H, m), 6.81-6.86 (1H, m).
References
[1] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 38
[2] Patent: WO2011/29392, 2011, A1
[3] Patent: WO2012/119559, 2012, A1
2-Fluoro-3-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-3-methoxyaniline manufacturers
- Product
- Benzenamine, 2-fluoro-3-methoxy- (9CI) 801282-00-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11