1-Chlorophenothiazine
- Product Name
- 1-Chlorophenothiazine
- CAS No.
- 1910-85-6
- Chemical Name
- 1-Chlorophenothiazine
- Synonyms
- 1-Chlorophenothiazine;Cyamemazine Impurity 10;1-chloro-10H-phenothiazine;10H-Phenothiazine,1-chloro-
- CBNumber
- CB61074273
- Molecular Formula
- C12H8ClNS
- Formula Weight
- 233.72
- MOL File
- 1910-85-6.mol
1-Chlorophenothiazine Property
- Melting point:
- 92 °C
- Boiling point:
- 392.3±31.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -2.98±0.20(Predicted)
- Appearance
- White to off-white Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C370010
- Product name
- 1-Chlorophenothiazine
- Packaging
- 100mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 409545
- Product name
- 1-Chlorophenothiazine
- Packaging
- 100mg
- Price
- $602
- Updated
- 2021/12/16
- Product number
- C370010
- Product name
- 1-Chlorophenothiazine
- Packaging
- 500mg
- Price
- $935
- Updated
- 2021/12/16
- Product number
- C370010
- Product name
- 1-Chlorophenothiazine
- Packaging
- 1g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 0959CC
- Product name
- 1-Chloro-10H-phenothiazine
- Packaging
- 250mg
- Price
- $188
- Updated
- 2021/12/16
1-Chlorophenothiazine Chemical Properties,Usage,Production
Uses
1-Chlorophenothiazine is used in electronic structure and physical-chemical properties relationship for phenothiazine derivatives by quantum chemical calculations.
Synthesis
2401-21-0
1204-55-3
1910-85-6
The general procedure for the synthesis of 1-chloro-10H-phenothiazine from 1,2-dichloro-3-iodobenzene and S-(2-acetamidophenyl) thioacetate was as follows: to an oven-dried 25 mL milled-mouth test tube fitted with a stirrer was added sequentially S-(2-acetamidophenyl) thioacetate (0.5 mmol), 1,2-dichloro-3-iodobenzene (0.6 mmol) , Cs2CO3 (2.0 mmol) and DMF (3 mL). The test tube was sealed with a sleeve rubber stopper, evacuated and replaced with argon for three cycles. The reaction mixture was stirred at 130°C for 10 hours. After completion of the reaction, it was cooled to room temperature, the reaction was quenched with water (20 mL) and extracted three times with ethyl acetate (20 mL). The organic layers were combined, dried with anhydrous MgSO4 and subsequently concentrated under vacuum on a rotary evaporator. Finally, the residue was purified by silica gel column chromatography using gradient elution (eluent: petroleum ether/ethyl acetate) to afford the target product 1-chloro-10H-phenothiazine.
References
[1] Synthetic Communications, 2017, vol. 47, # 7, p. 710 - 715
1-Chlorophenothiazine Preparation Products And Raw materials
Raw materials
Preparation Products
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