Neticonazole

ChemicalBook > CAS DataBase List > Neticonazole

Product Name: Neticonazole
CAS No.: 130726-68-0
Chemical Name: Neticonazole
Synonyms: Neticonazole;Neticonazolehyd;Naconazole hydrochloride;1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole;1-[(E)-2-Methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl]-1H-imidazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-{(E)-2-(Methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole;1H-Imidazole, 1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-
CBNumber: CB61075063
Molecular Formula: C17H22N2OS
Formula Weight: 302.43
MOL File: 130726-68-0.mol

Less

Neticonazole Property

Melting point:: 37-39°
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (826.64 mM)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0026017
Product name: Neticonazole
Purity: 99.46%
Packaging: 25mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-0026017
Product name: Neticonazole
Purity: 99.46%
Packaging: 50mg
Price: $135
Updated: 2021/12/16

ChemScene

Product number: CS-0026017
Product name: Neticonazole
Purity: 99.46%
Packaging: 100mg
Price: $220
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008722
Product name: NETICONAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $500.02
Updated: 2021/12/16

Less

Neticonazole Chemical Properties,Usage,Production

Definition

ChEBI: Neticonazole is an enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections. It has a role as an antifungal drug and an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is an aromatic ether, a methyl sulfide, a member of imidazoles, an enamine, a member of benzenes, a conazole antifungal drug and an imidazole antifungal drug. It is a conjugate base of a neticonazole(1+).

Biological Activity

Neticonazole, an imidazole derivative, is also a potent and long-acting antifungal agent. It has anti-infective and anti-cancer properties.

in vitro

Neticonazole (10 μM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 μM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
It is also an orally active exosome biogenesis and secretion inhibitor.

Western Blot Analysis

td>

Cell Line:	C4-2B cells
Concentration:	10 μM
Incubation Time:	48 hours
Result:	Deccreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.

in vivo

Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors , likely through increasing apoptosis of CRC xenograft tumor cells.

td>

Animal Model:	Male C57BL/6 mice (8 weeks old) given ampicillin , neomycin, metronidazole and vancomycin, and injected with SW480 cells
Dosage:	1 ng/kg , 10 ng/kg and 100 ng/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Significantly improved the survival of IDB mice with CRC xenograft tumors.

target

Fungal

Neticonazole Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Neticonazole Suppliers

China 41 Germany 1 South Korea 1 United States 5 Global 48

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3423
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17994
Advantage: 56

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q3382968513
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 3151
Advantage: 55

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: order@changyanchem.com
Country: China
ProdList: 5008
Advantage: 55

ChangSha kangpeng Pharmaceutical Co., Ltd.

Tel: 18229909706
Fax: -
Email: 3249713892@qq.com
Country: China
ProdList: 82
Advantage: 55

Shanghai CP Pharmaceutical Technology Co., Ltd.

Tel: 18221530285
Fax: -
Country: China
ProdList: 489
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3501
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3980
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 1981
Advantage: 58

Jinan Guoding Pharmaceutical Technology Co., Ltd.

Tel: 15665775653
Fax: 053167801621
Email: sales@guodingpharma.com
Country: China
ProdList: 481
Advantage: 58

Nanjing Qishi Biotechnology Co. Ltd.

Tel: 19822610310
Email: 3122922726@qq.com
Country: China
ProdList: 1346
Advantage: 58

Zhejiang Zetian Fine Chemical Co., Ltd.

Tel: 0571-0571-0571-87682782 18957127338
Fax: QQ800182836
Email: sales@zetchem.com
Country: China
ProdList: 573
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25363
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551 18958018566;
Fax: 008657185134895
Email: info@afinechem.com
Country: China
ProdList: 15377
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 17825480238
Fax: QQ 3008233717
Email: 3008233717@qq.com
Country: China
ProdList: 9843
Advantage: 12

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10326
Advantage: 58

SIMAGCHEM CORP

Tel: +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17367
Advantage: 58

Xiamen AmoyChem Co., Ltd

Tel: +86-592-6051114 +8618959220845
Email: sales@amoychem.com
Country: China
ProdList: 6387
Advantage: 58

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14253
Advantage: 58

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 4278
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9215
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10951
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 61720
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9934
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13053322091 13053322091
Email: admin@mopaikeji.com
Country: China
ProdList: 10974
Advantage: 58

Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

Tel: 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 9887
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48467
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: 3674309880
Email: hanfangpharma@126.com
Country: China
ProdList: 30968
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9180
Advantage: 58

Hubei Moco Chemical Co., Ltd.

Tel: 18627756402
Fax: QQ：3001051413
Email: 3001051413@qq.com
Country: China
ProdList: 10441
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.com
Country: China
ProdList: 24246
Advantage: 58

Zhejiang ZETian Fine Chemicals Co. LTD

Tel: 18957127338
Email: stella@zetchem.com
Country: China
ProdList: 2141
Advantage: 58

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8617865335152
Email: Mandy@hangyubiotech.com
Country: China
ProdList: 11013
Advantage: 58

Jewim Pharmaceutical (Shandong) Co., Ltd.

Tel: +86-15552509998 +86-15621883869
Email: liutf@jewim.com.cn
Country: China
ProdList: 251
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

130726-68-0, NeticonazoleRelated Search:

Itraconazole Voriconazole

Neticonazole

1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole

1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl]-1H-imidazole

1-[(E)-2-Methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole

1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole

1-{(E)-2-(Methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole

1H-Imidazole, 1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-

Naconazole hydrochloride

Neticonazolehyd

(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole

130726-68-0

Intermediate of Neticonazole Hydrochloride

MSDS|CAS|CAS DataBase|New Products
Contact us|Computer Version
Chemical Book