ChemicalBook > CAS DataBase List > BLU-945
BLU-945
- Product Name
- BLU-945
- CAS No.
- 2660250-10-0
- Chemical Name
- BLU-945
- Synonyms
- BLU-945;N-[2-[(3S,4R)-3-fluoro-4-methoxy-1-piperidyl]pyrimidin-4-yl]-5-isopropyl-8-[(2R,3S)-2-methyl-3-(methylsulfonylmethyl)azetidin-1-yl]isoquinolin-3-amine;N-[2-[(3S,4R)-3-Fluoro-4-methoxy-1-piperidyl]-4-pyrimidinyl]-5-isopropyl-8-[(2R,3S)-2-methyl-3-[(methylsulfonyl)methyl]-1-azetidinyl]isoquinolin-3-amine;N-(2-((3S,4R)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)-5-isopropyl-8-((2R,3S)-2-methyl-3-((methylsulfonyl)methyl)azetidin-1-yl)isoquinolin-3-amine;N-{2-[(3S,4R)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}-8-[(2R,3S)-3-(methanesulfonylmethyl)-2-methylazetidin-1-yl]-5-(propan-2-yl)isoquinolin-3-amine;3-Isoquinolinamine, N-[2-[(3S,4R)-3-fluoro-4-methoxy-1-piperidinyl]-4-pyrimidinyl]-5-(1-methylethyl)-8-[(2R,3S)-2-methyl-3-[(methylsulfonyl)methyl]-1-azetidinyl]-
- CBNumber
- CB610776751
- Molecular Formula
- C28H37FN6O3S
- Formula Weight
- 556.7
- MOL File
- 2660250-10-0.mol
More
Less
BLU-945 Property
- Boiling point:
- 784.6±70.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 7.87±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- InChI
- InChI=1/C28H37FN6O3S/c1-17(2)20-6-7-24(35-14-19(18(35)3)16-39(5,36)37)22-13-31-27(12-21(20)22)32-26-8-10-30-28(33-26)34-11-9-25(38-4)23(29)15-34/h6-8,10,12-13,17-19,23,25H,9,11,14-16H2,1-5H3,(H,30,31,32,33)/t18-,19-,23+,25-/s3
- InChIKey
- LIMFPAAAIVQRRD-MCEZSBKONA-N
- SMILES
- C(C1=CC=C(N2C[C@H](CS(=O)(=O)C)[C@H]2C)C2C=NC(NC3C=CN=C(N4CC[C@@H](OC)[C@@H](F)C4)N=3)=CC1=2)(C)C |&1:7,13,28,31,r|
More
Less
BLU-945 Chemical Properties,Usage,Production
Description
BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It can effectively inhibit EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation. BLU-945 can be used for research on lung cancer, including non-small cell lung cancer (NSCLC)[1].
Chemical Properties
IUPAC/Chemical Name: N-(2-((3S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)-5-isopropyl-8-((2R,3S)-2-methyl-3-((methylsulfonyl)methyl)azetidin-1-yl)isoquinolin-3-amine.
Side effects
According to clinical studies of BLU-945, common side effects of BLU-945 monotherapy include: rash, diarrhoea, nausea, vomiting, headache, dry skin, onychomycosis, and elevated alanine aminotransferase and aspartate aminotransferase. Common side effects of the combination of BLU-945 and ositinib include: headache, nausea, fatigue, decreased appetite, vomiting, diarrhoea, dry skin, acne-like dermatitis and onychomycosis.
in vitro
BLU-945 has inhibitory activity against the EGFRm/T790M double and EGFRm/T790M/C797Striple mutants with IC50 value range from 1.2-4.4 nM.
BLU-945 (0- 10 mM, 4 h) inhibit EGFR phosphorylation in the EGFR L858R/T790M/C797S, and EGFR ex19del/T790M/C797S mutant cell lines.
References
[1] Y. Elamin. “BLU-945 monotherapy and in combination with osimertinib (OSI) in previously treated patients with advanced EGFR-mutant (EGFRm) NSCLC in the phase 1/2 SYMPHONY study.” Journal of Clinical Oncology (2023).
BLU-945 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
BLU-945 Suppliers
- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1843
- Advantage
- 55
- Tel
- 13606124132;13656121842
- luyan0021@163.com
- Country
- China
- ProdList
- 219
- Advantage
- 58
- Tel
- +21-18501659228 18501659228
- Fax
- sales@hope-chem.com
- info@hope-chem.com
- Country
- China
- ProdList
- 481
- Advantage
- 55
- Tel
- 13720134139 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 5797
- Advantage
- 58
- Tel
- 0512-88968486 18012631750
- sales@albertchemical.com
- Country
- China
- ProdList
- 285
- Advantage
- 58
- Tel
- 0512-68780025 18962125825
- sales@ryanchem.com
- Country
- China
- ProdList
- 163
- Advantage
- 62
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 13268215580
- scinova_sales@163.com
- Country
- China
- ProdList
- 7023
- Advantage
- 58
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 021-20962833 15316628753
- Fax
- 021-2096-2832
- sales@pansopharm.com
- Country
- China
- ProdList
- 533
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4512
- Advantage
- 55
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2991
- Advantage
- 58
- Tel
- 021-54338626 18017892860
- Fax
- 021-54338626
- sales@tubepharm.com
- Country
- China
- ProdList
- 2416
- Advantage
- 58
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3061
- Advantage
- 58
- Tel
- 15006117673
- Fax
- 2973592490@.com
- 2973592490@qq.com
- Country
- China
- ProdList
- 298
- Advantage
- 58
- Tel
- 13917833665
- lyg@world-goldpharma.com
- Country
- China
- ProdList
- 151
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3600
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 11725
- Advantage
- 58
- Tel
- 055-58228005 18151793555
- 413315120@qq.com
- Country
- China
- ProdList
- 162
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 4297
- Advantage
- 58
- Tel
- 025-85563444 15850508050
- Fax
- 18013869214
- rose.shi@synzest.com
- Country
- China
- ProdList
- 269
- Advantage
- 58
- Tel
- +86-15850508050 +86-15850508050
- Fax
- (+86)25-85563444
- sean.lv@synzest.com
- Country
- China
- ProdList
- 323
- Advantage
- 58
- Tel
- 021-20432219 13918097649
- Fax
- QQ79021576
- li_jinfei@acblock-lab.com
- Country
- China
- ProdList
- 9964
- Advantage
- 58
- Tel
- 18164232327
- 2709603029@qq.com
- Country
- China
- ProdList
- 291
- Advantage
- 58
- Tel
- 18367323072
- 2125193158@qq.com
- Country
- China
- ProdList
- 367
- Advantage
- 58
- Tel
- 18696113233
- Fax
- QQ:2544920688
- like1076463918@163.com
- Country
- China
- ProdList
- 3273
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62163
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ：2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 10715
- Advantage
- 58
- Tel
- 0371-55013243 15324716602
- 2853979810@qq.com
- Country
- China
- ProdList
- 10018
- Advantage
- 58
- Tel
- 18696113233
- 15927219311@163.com
- Country
- China
- ProdList
- 1626
- Advantage
- 58
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
- Country
- China
- ProdList
- 2565
- Advantage
- 58
- Tel
- 13417589054 13417589054
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 9470
- Advantage
- 58
- Tel
- 13421666688 13421666688
- 664261110@qq.com
- Country
- China
- ProdList
- 410
- Advantage
- 58
- Tel
- 0533-6092686 13371592196
- ddliu@bio-polar.cn
- Country
- China
- ProdList
- 1624
- Advantage
- 58
- Tel
- 19713077352
- 1038096457@qq.com
- Country
- China
- ProdList
- 2918
- Advantage
- 58
- Tel
- 17362916295; 17362916295
- w17362916295@163.com
- Country
- China
- ProdList
- 4046
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- +86-0576-88827176 +86-18906581668
- post@creatingchemical.com
- Country
- China
- ProdList
- 229
- Advantage
- 58
- Tel
- 18271874579; 18271874579
- 2176439072@qq.com
- Country
- China
- ProdList
- 268
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- cb5@aikonchem.com
- Country
- China
- ProdList
- 10528
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29977
- Advantage
- 58
- Tel
- 18860950986
- tangmanman@lebangpharma.com
- Country
- China
- ProdList
- 538
- Advantage
- 58
- Tel
- 027-027-16602739303 16602739303
- 673003916@qq.com
- Country
- China
- ProdList
- 3059
- Advantage
- 58
- Tel
- 18055651951
- 2272561977@qq.com
- Country
- China
- ProdList
- 420
- Advantage
- 58
- Tel
- 18164002430
- 511710754@qq.com
- Country
- China
- ProdList
- 228
- Advantage
- 58
- Tel
- 17721492509
- 643638326@qq.com
- Country
- China
- ProdList
- 5345
- Advantage
- 58