ChemicalBook > CAS DataBase List > 5-bromo-7-fluoro-1H-indole
5-bromo-7-fluoro-1H-indole
Uses- Product Name
- 5-bromo-7-fluoro-1H-indole
- CAS No.
- 883500-73-0
- Chemical Name
- 5-bromo-7-fluoro-1H-indole
- Synonyms
- 5-Bromo-8-fluoroindole;5-bromo-7-fluoro-1H-indole;1H-Indole, 5-broMo-7-fluoro-
- CBNumber
- CB61078150
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 883500-73-0.mol
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5-bromo-7-fluoro-1H-indole Property
- Melting point:
- 28-32°C
- Boiling point:
- 315.1±22.0 °C(Predicted)
- Density
- 1.750±0.06 g/cm3(Predicted)
- Flash point:
- >110℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.58±0.30(Predicted)
- Appearance
- white solid or yellow liquid
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B804270
- Product name
- 5-Bromo-7-fluoro-1H-indole
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 009819
- Product name
- 5-Bromo-7-fluoroindole
- Purity
- 95%
- Packaging
- 250mg
- Price
- $128
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC6967
- Product name
- 5-Bromo-7-fluoro-1H-indole
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 009819
- Product name
- 5-Bromo-7-fluoroindole
- Purity
- 95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-B-Y6
- Product name
- 5-Bromo-7-fluoro-1H-indole
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
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5-bromo-7-fluoro-1H-indole Chemical Properties,Usage,Production
Uses
5-Bromo-7-fluoroindole can be used as a pharmaceutical synthesis intermediate.
Synthesis
321-23-3
1826-67-1
883500-73-0
Vinylmagnesium bromide (1M solution in THF, 13.62 mL, 13.62 mmol) was added slowly and dropwise to a solution of 4-bromo-2-fluoro-1-nitrobenzene (1.0 g, 4.54 mmol) in tetrahydrofuran (THF, 20 mL) at -40 °C. The reaction mixture was stirred at this temperature for 60 minutes. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride (NH4Cl) and the mixture was extracted with ethyl acetate (EtOAc, 2 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated to dryness under reduced pressure. Purification by fast column chromatography (silica gel, ethyl acetate: petroleum ether = 9:1) afforded 5-bromo-7-fluoro-1H-indole as a gel solid (0.24 g, 25% yield).
References
[1] European Journal of Organic Chemistry, 2006, # 13, p. 2956 - 2969
[2] Patent: US2012/252853, 2012, A1. Location in patent: Page/Page column 30
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View Lastest Price from 5-bromo-7-fluoro-1H-indole manufacturers
Career Henan Chemical Co
- Product
- 5-bromo-7-fluoro-1H-indole 883500-73-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08
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