2,4-Pyrimidinediamine, 6-methyl- (9CI)
- Product Name
- 2,4-Pyrimidinediamine, 6-methyl- (9CI)
- CAS No.
- 1791-73-7
- Chemical Name
- 2,4-Pyrimidinediamine, 6-methyl- (9CI)
- Synonyms
- 6-Methylpyrimidine-2,4-diamine;6-Methyl-2,4-pyrimidinediamine;2,4-Pyrimidinediamine,6-methyl-;2,4-Pyrimidinediamine, 6-methyl- (9CI);(2-amino-6-methyl-pyrimidin-4-yl)amine;2,4-Pyrimidinediamine, 6-methyl- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB61081189
- Molecular Formula
- C5H8N4
- Formula Weight
- 124.14
- MOL File
- 1791-73-7.mol
2,4-Pyrimidinediamine, 6-methyl- (9CI) Property
- Melting point:
- 183-185 °C
- Boiling point:
- 389.5±34.0 °C(Predicted)
- Density
- 1.283±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 7.81±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M222613
- Product name
- 6-Methyl-2,4-pyrimidinediamine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- M222613
- Product name
- 6-Methyl-2,4-pyrimidinediamine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Z4305
- Product name
- 6-Methyl-2,4-pyrimidinediamine
- Packaging
- 250mg
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 3H30-1-0P
- Product name
- 6-Methylpyrimidine-2,4-diamine
- Packaging
- 1g
- Price
- $408
- Updated
- 2021/12/16
- Product number
- CHM0391432
- Product name
- 6-METHYL-2,4-PYRIMIDINEDIAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.76
- Updated
- 2021/12/16
2,4-Pyrimidinediamine, 6-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
1118-61-2
50-01-1
1791-73-7
The general procedure for the synthesis of 6-methyl-2,4-pyrimidinediamines from 3-aminobut-2-enenenitrile and guanidine hydrochloride was carried out as follows: according to the method described in Aust. J. Chem. 1984, vol. 37, pp. 1195-1201. First, guanidine hydrochloride (23.8 g) was added to a methanol solution (51 mL) of methanol (50 mL) and 28% sodium methanol and stirred for 30 min at room temperature. Subsequently, the precipitated salt was removed by filtration and the solution was concentrated under reduced pressure to give a solution of the product without guanidine. Next, 3-aminobut-2-enenenitrile (16.4 g) and 1-butanol (60 mL) were added to this solution. The reaction mixture was heated and stirred at 110 °C for 10 h under nitrogen protection. Upon completion of the reaction, the precipitated salt was removed by thermal filtration, and acetone (100 mL) was added to the filtrate and stirred under ice bath cooling for 30 min to obtain the crude product. The crude product was recrystallized by acetone to give 2,4-diamino-6-methylpyrimidine (10.5 g). Next, methyl benzoate (23 g, 169 mmol) and sodium methanol (22 g, 407 mmol) were added to a solution of N-ethylpyrrolidone (100 mL) in 2,4-diamino-6-methylpyrimidine (10 g, 81 mmol) and stirred under heat at 40 °C for 2 hours. Upon completion of the reaction, the reaction system was cooled to room temperature, poured into a 1N aqueous hydrochloric acid solution and filtered to collect the solid. The crude product was recrystallized by 2-propanol to give the target compounds (1-2). Finally, compounds (1-2) were subjected to NMR spectroscopic analysis with the following results: 1H-NMR (solvent: d6-DMSO, internal standard: tetramethylsilane) δ (ppm) 2.50 (3H, s), 7.45-7.70 (6H, m), 7.90 (1H, s), 7.95-8.05 (4H, m), 10.88 (1H, s), 11.10 (1H, s).
References
[1] Australian Journal of Chemistry, 1984, vol. 37, # 6, p. 1195 - 1201
[2] Patent: US2016/159750, 2016, A1. Location in patent: Paragraph 0361-0365
2,4-Pyrimidinediamine, 6-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Pyrimidinediamine, 6-methyl- (9CI) manufacturers
- Product
- 2,4-Pyrimidinediamine, 6-methyl- (9CI) 1791-73-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-11