4-FLUOROPHENYL ACETIC HYDRAZIDE
- Product Name
- 4-FLUOROPHENYL ACETIC HYDRAZIDE
- CAS No.
- 34547-28-9
- Chemical Name
- 4-FLUOROPHENYL ACETIC HYDRAZIDE
- Synonyms
- 4-FLUOROPHENYLACETYL HYDRAZINE;P-FLUOROPHENYLACETYL HYDRAZINE;4-flourophenyl acetic hydrazide;4-FLUOROPHENYL ACETIC HYDRAZIDE;Of acetyl hydrazine fluorophenyl;4-Fluorophenylacetic acid hydrazide;4-Fluorobenzeneacetic acid hydrazide;Benzeneacetic acid, 4-fluoro-, hydrazide
- CBNumber
- CB6108663
- Molecular Formula
- C8H9FN2O
- Formula Weight
- 168.17
- MOL File
- 34547-28-9.mol
4-FLUOROPHENYL ACETIC HYDRAZIDE Property
- Boiling point:
- 370.6±25.0 °C(Predicted)
- Density
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 13.06±0.18(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- A092
- Product name
- 4-Fluorophenylacetylhydrazine
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- AK-87254
- Product name
- 2-(4-Fluorophenyl)acetohydrazide
- Purity
- 97%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- HCH0314366
- Product name
- 4-FLUOROPHENYLACETIC HYDRAZIDE
- Purity
- 98.00%
- Packaging
- 5MG
- Price
- $497.74
- Updated
- 2021/12/16
- Product number
- A340054
- Product name
- 2-(4-Fluorophenyl)acetohydrazide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $9
- Updated
- 2021/12/16
- Product number
- A340054
- Product name
- 2-(4-Fluorophenyl)acetohydrazide
- Purity
- 97%
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
4-FLUOROPHENYL ACETIC HYDRAZIDE Chemical Properties,Usage,Production
Uses
4-Fluorophenylacetic hydrazide
Synthesis
459-04-1
34547-28-9
The general procedure for the synthesis of 2-(4-fluorophenyl)acetylhydrazine from 4-fluorophenylacetyl chloride was as follows: a solution of hydrazine (4.5 M, 144 mmol) in dichloromethane (50 mL) was added slowly and dropwise to a solution of (4-fluorophenyl)acetyl chloride (1.0 g, 5.8 mmol) in dichloromethane at 0 °C. The reaction mixture was stirred at 0 °C for 40 min. Subsequently, the reaction was terminated by addition of water. The organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane. All organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure and purified by fast column chromatography (elution gradient: 5% methanol-dichloromethane) to afford 2-(4-fluorophenyl)acetohydrazide (673 mg, 69% yield) as a white solid. The product was characterized by 1H NMR (DMSO-D6): δ 9.18 (broad peak, 1H), 7.26 (dd, J = 8.4, 5.7 Hz, 2H), 7.09 (t, J = 8.4 Hz, 2H), 4.21 (broad peak, 2H), 3.31 (s, 2H); mass spectrum (MS) showed m/z 169 ([M + H]+).
References
[1] Medicinal Chemistry, 2014, vol. 10, # 8, p. 810 - 823
[2] Patent: WO2004/101512, 2004, A2. Location in patent: Page 55
[3] Patent: WO2007/50510, 2007, A2. Location in patent: Page/Page column 38
[4] Patent: WO2011/46873, 2011, A1. Location in patent: Page/Page column 29
[5] Patent: WO2011/120153, 2011, A1
4-FLUOROPHENYL ACETIC HYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUOROPHENYL ACETIC HYDRAZIDE manufacturers
- Product
- 4-FLUOROPHENYL ACETIC HYDRAZIDE 34547-28-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03