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LADOSTIGIL

Product Name
LADOSTIGIL
CAS No.
209394-27-4
Chemical Name
LADOSTIGIL
Synonyms
LADOSTIGIL;Ladostigil (TV-3,326);Ladostigil, 10 mM in DMSO;LHXOCOHMBFOVJS-OAHLLOKOSA-N;TV-3326|||Ladostigil|||TV 3326|||TV3326|||Ladostigil free base;Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester
CBNumber
CB61086801
Molecular Formula
C16H20N2O2
Formula Weight
272.34
MOL File
209394-27-4.mol
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LADOSTIGIL Property

Boiling point:
412.4±45.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
pka
6.94±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0013973
Product name
LADOSTIGIL
Purity
95.00%
Packaging
5MG
Price
$495.8
Updated
2021/12/16
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LADOSTIGIL Chemical Properties,Usage,Production

Uses

Treatment of Alzheimer’s disease (an inhibitor of monoamine oxidase (MAO-A and B), an acetylcholinesterase inhibitor, and a neuroprotectant).

Definition

ChEBI: Ladostigil is a member of indanes.

in vivo

Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4].
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats[3].

Animal Model:Pathogen-free (SPF) Sprague-Dawley rats[4]
Dosage:17 mg/kg
Administration:P.o. (added to the drinking water) daily for 6 weeks
Result:Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST.

IC 50

MAO-B: 37.1 μM (IC50); AChE: 31.8 μM (IC50)

LADOSTIGIL Preparation Products And Raw materials

Raw materials

Preparation Products

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LADOSTIGIL Suppliers

CHINA 9 United Kingdom 1 United States 4 USA 1 Global 15
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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70
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

209394-27-4, LADOSTIGILRelated Search:


  • LADOSTIGIL
  • Ladostigil (TV-3,326)
  • LHXOCOHMBFOVJS-OAHLLOKOSA-N
  • Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester
  • TV-3326|||Ladostigil|||TV 3326|||TV3326|||Ladostigil free base
  • Ladostigil, 10 mM in DMSO
  • 209394-27-4
  • 209349-27-4