ChemicalBook > CAS DataBase List > 3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE

3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE

Product Name
3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE
CAS No.
1192-80-9
Chemical Name
3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE
Synonyms
1,2,4-Oxadiazole, 3-(chloroMethyl)-5-Methyl-;3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole 98%;3-(chloromethyl)-5-methyl-1,2,4-oxadiazole(SALTDATA: FREE)
CBNumber
CB61092558
Molecular Formula
C4H5ClN2O
Formula Weight
132.55
MOL File
1192-80-9.mol
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3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE Property

Boiling point:
76-77 °C(Press: 15 Torr)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
-1.10±0.32(Predicted)
form 
liquid
color 
Colourless
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Safety

HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B419268
Product name
3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC127158
Product name
3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole
Packaging
100mg
Price
$72
Updated
2021/12/16
AK Scientific
Product number
3299AA
Product name
3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole
Packaging
1g
Price
$74
Updated
2021/12/16
Matrix Scientific
Product number
058870
Product name
3-Chloromethyl-5-methyl-[1,2,4]oxadiazole
Purity
95+%
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR300629
Product name
3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole
Packaging
1g
Price
$135
Updated
2021/12/16
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3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE Chemical Properties,Usage,Production

Synthesis

108-24-7

3272-96-6

1192-80-9

2-Chloro-N'-hydroxyacetamidine (217 mg, 2 mmol) was mixed with ethanoic anhydride (224.4 mg, 2.2 mmol) in dichloromethane (2 mL) at room temperature and reacted for 1 hour. N,N-dimethylformamide (1 mL) was then added and the reaction mixture was heated at 130 °C for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium carbonate solution and extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the crude product 3-(chloromethyl)-5-methyl-1,2,4-oxadiazole (59 mg, 22.2% yield) as a yellow oil, which could be used in subsequent reactions without further purification.1H NMR (CDCl3, δ ppm): 4.41 (s, 2H), 2.55 (s, 3H).

References

[1] Patent: WO2004/14902, 2004, A2. Location in patent: Page 43
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973, p. 2769 - 2772

3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE Suppliers

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1192-80-9, 3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLERelated Search:

3-(CHLOROMETHYL)-5-(4-METHOXYPHENYL)-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-(3-THIENYL)-1,2,4-OXADIAZOLE 3-Chloromethyl-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole 3-(CHLOROMETHYL)-5-(2-METHOXYPHENYL)-1,2,4-OXADIAZOLE 3-(Chloromethyl)-5-phenyl-1,2,4-oxadiazole 5-(TERT-BUTYL)-3-(CHLOROMETHYL)-1,2,4-OXADIAZOLE 3-[3-(CHLOROMETHYL)-1,2,4-OXADIAZOL-5-YL]-2-(METHYLTHIO)PYRIDINE 3-(CHLOROMETHYL)-5-METHYL-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-(3-METHOXYPHENYL)-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-(3,5-DIMETHYLISOXAZOL-4-YL)-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-(2-THIENYL)-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-CYCLOBUTYL-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)-1,2,4-OXADIAZOLE 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-3-(CHLOROMETHYL)-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-(1,2,3-THIADIAZOL-4-YL)-1,2,4-OXADIAZOLE 3-CHLOROMETHYL-5-(FUR-2-YL)-1,2,4-OXADIAZOLE 3-(CHLOROMETHYL)-5-(3,4-DICHLOROPHENYL)-1,2,4-OXADIAZOLE

  • 3-(chloromethyl)-5-methyl-1,2,4-oxadiazole(SALTDATA: FREE)
  • 1,2,4-Oxadiazole, 3-(chloroMethyl)-5-Methyl-
  • 3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole 98%
  • 1192-80-9