2-FLUORO-6-NITRO-PHENYLAMINE
- Product Name
- 2-FLUORO-6-NITRO-PHENYLAMINE
- CAS No.
- 17809-36-8
- Chemical Name
- 2-FLUORO-6-NITRO-PHENYLAMINE
- Synonyms
- Einecs 241-779-9;2-FLUORO-6-NITROANILINE;2-Nitro-6-fluoroaniline;2-Fluoro-6-nitroaniline98%;2-Fluoro-6-nitroaniline 98%;6-AMino-2-Fluoronitrobenzene;2-Amino-3-fluoronitrobenzene;2-FLUORO-6-NITRO-PHENYLAMINE;Benzenamine, 2-fluoro-6-nitro-;2-FLUORO-6-NITRO-PHENYLAMINE ISO 9001：2015 REACH
- CBNumber
- CB6109998
- Molecular Formula
- C6H5FN2O2
- Formula Weight
- 156.11
- MOL File
- 17809-36-8.mol
2-FLUORO-6-NITRO-PHENYLAMINE Property
- Melting point:
- 74-75
- Boiling point:
- 271.5±20.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- -1.76±0.25(Predicted)
- color
- Yellow/orange
- InChI
- InChI=1S/C6H5FN2O2/c7-4-2-1-3-5(6(4)8)9(10)11/h1-3H,8H2
- InChIKey
- BHWHYGWMNMCXBA-UHFFFAOYSA-N
- SMILES
- C1(N)=C([N+]([O-])=O)C=CC=C1F
- CAS DataBase Reference
- 17809-36-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 29214990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B434828
- Product name
- 2-Fluoro-6-nitroaniline
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-D0998
- Product name
- 2-Fluoro-6-nitroaniline
- Packaging
- 5g
- Price
- $57
- Updated
- 2021/12/16
- Product number
- 074086
- Product name
- 2-Fluoro-6-nitroaniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC10555
- Product name
- 2-Fluoro-6-nitroaniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- CS-D0998
- Product name
- 2-Fluoro-6-nitroaniline
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
2-FLUORO-6-NITRO-PHENYLAMINE Chemical Properties,Usage,Production
Chemical Properties
light yellow powder
Uses
2-Fluoro-6-nitro-phenylamine is mainly used as a pharmaceutical intermediate for the synthesis of specific drug molecules, such as anti-tumor drugs, antibacterial agents, etc.
Synthesis
342-52-9
17809-36-8
General procedure for the synthesis of 2-fluoro-6-nitroaniline from N-(2-fluoro-6-nitrophenyl)acetamide: 3 g (0.0151 mol) of N-(2-fluoro-6-nitrophenyl)acetamide (3a) was dissolved in 30 mL of concentrated H2SO4 and the reaction was stirred for 2 hr at 50 °C. After completion of the reaction, it was cooled to room temperature and the reaction solution was slowly poured into an ice bath and a large amount of precipitate was observed to be generated. The precipitate was collected by filtration and the acidic aqueous solution was extracted with ether. Purification by fast column chromatography afforded the target compound 2-fluoro-6-nitroaniline in 74% yield. The melting point of the product was 47-48 °C. 1H NMR (DMSO-d6) data: δ 7.82 (d, 1H, J=8.8 Hz, H-5), 7.42 (m, 1H, H-3), 7.25 (s, 2H, NH2), 6.63 (m, 1H, H-4). GC/MS analysis showed the molecular ion peak as 157 (M+H). Elemental analysis (C6H5FN2O2) Calculated values: C, 46.16; H, 3.23; F, 12.17; N, 17.94. Measured values: C, 46.18; H, 3.27; F, 12.15; N, 17.98.
References
[1] European Journal of Medicinal Chemistry, 2019, vol. 161, p. 399 - 415
[2] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976, vol. 30, p. 141 - 149
2-FLUORO-6-NITRO-PHENYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-6-NITRO-PHENYLAMINE manufacturers
- Product
- 2-FLUORO-6-NITRO-PHENYLAMINE 17809-36-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 2-FLUORO-6-NITRO-PHENYLAMINE 17809-36-8
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 2-Fluoro-6-nitroaniline 17809-36-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-07