Desirudin

Product Name: Desirudin
CAS No.: 120993-53-5
Chemical Name: Desirudin
Synonyms: K-HIR02;Desirudin
CBNumber: CB61116647
Molecular Formula: C287H440N80O110S6
Formula Weight: 6963.4245
MOL File: 120993-53-5.mol

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0009460
Product name: DESIRUDINE
Purity: 95.00%
Packaging: 5MG
Price: $497.95
Updated: 2021/12/16

More

Less

Desirudin Chemical Properties,Usage,Production

Uses

Anticoagulant.

Clinical Use

Prophylaxis of DVT in patients undergoing orthopaedic surgery

in vivo

Desirudin (CGP 39393, 0.75-3.0 mg/kg, a bolus plus infusion administration, dogs model of cardiopulmonary bypass) is effective in Inhibiting clot formation^[1]. Desirudin (0.01-1 mg/kg, Intravenous injections and subcutaneous injection, rat shunt model) inhibits thrombus development with ED₅₀ values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.), and inhibits venous stasis thrombosis with ED₅₀ values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)^[2].

Animal Model:	Male mongrel dogs model of cardiopulmonary bypass^[1]
Dosage:	1.0 mg/kg + 0.75 mg/kg/h, 1.0 mg/kg + 1.50 mg/kg/h, 1.0 mg/kg + 2.25 mg/kg/h, 1.0 mg/kg + 3.0 mg/kg/h.
Administration:	Administered as a bolus plus infusion
Result:	Inhibited clot formation with no adverse hemodynamic or hematologic effects.

Animal Model:	Rat shunt model of thrombus formation on a cotton-thread^[2]
Dosage:	0.01-1 mg/kg approximately
Administration:	Intravenous injections, subcutaneous injection
Result:	Inhibited thrombus development with ED₅₀ values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.). Inhibited venous stasis thrombosis with ED₅₀ values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.).

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants, antiplatelets, fondaparinux, NSAIDs, heparin and dextran - increased risk of bleeding

Metabolism

Desirudin is metabolised and excreted by the kidney, and 40-50% of a dose is excreted unchanged in the urine

Desirudin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Desirudin Suppliers

China 21 United Kingdom 1 United States 6 Global 28

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Nanjing chengqimei Biotechnology Co., Ltd

Tel: 19850819832
Email: 2173594524@qq.com
Country: China
ProdList: 2638
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 13675144456
Email: alan.chow@synzest.com
Country: China
ProdList: 9470
Advantage: 58

Chengdu Jinglin Biotechnology Co., Ltd.

Tel: 17711399154
Email: 3211919385@qq.com
Country: China
ProdList: 1815
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6979
Advantage: 58

HUBEI HICKS BIOCHEMICAL CO.,LTD

Tel: 18696113233
Email: 15927219311@163.com
Country: China
ProdList: 1660
Advantage: 58

Shanghai HongTide Biotechnology Co.,Ltd.

Tel: 15318089928
Email: alex@hanhonggroup.com
Country: China
ProdList: 4604
Advantage: 58

Hubei Hicks Biochemical Co., Ltd

Tel: 17362916295; 17362916295
Email: w17362916295@163.com
Country: China
ProdList: 3992
Advantage: 58

Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd

Tel: 13770887460
Email: wenxi@jszkhy.com
Country: China
ProdList: 1354
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

LEON (NANJING) BIOTECHNOLOGY CO., LTD.

Tel: +8615051830413
Email: sales.njleonbiotech@gmail.com
Country: China
ProdList: 5482
Advantage: 58

Changsha MOL Changes Biotechnology Co., Ltd.

Tel: +8619375158599
Email: info@molchanges.com
Country: China
ProdList: 5218
Advantage: 58

Lanospharma Laboratories Co.,Ltd

Tel: --
Fax: --
Email: sales@lanospharma.com
Country: China
ProdList: 6329
Advantage: 56

120993-53-5, DesirudinRelated Search:

Apixaban Linezolid Argatroban Bivalirudin

Desirudin

K-HIR02

120993-53-5

C287H440N80O110S6