Terbufibrol
- Product Name
- Terbufibrol
- CAS No.
- 56488-59-6
- Chemical Name
- Terbufibrol
- Synonyms
- K-11267;Terbufibrol;Reaxys ID: 2949416;Terbufibrol, 10 mM in DMSO;p-[3-(p-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acid;p-[[3-(p-t-Butylphenoxy)-2-hydroxypropyl]oxy]benzoic acid;Benzoic acid, 4-[3-[4-(1,1-dimethylethyl)phenoxy]-2-hydroxypropoxy]-
- CBNumber
- CB61117028
- Molecular Formula
- C20H24O5
- Formula Weight
- 344.4
- MOL File
- 56488-59-6.mol
Terbufibrol Property
- Boiling point:
- 439.5°C (rough estimate)
- Density
- 1.1444 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 4.41±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- API0012593
- Product name
- TERBUFIBROL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.18
- Updated
- 2021/12/16
Terbufibrol Chemical Properties,Usage,Production
Uses
Terbufibrol has been shown highly active in reducing serum total cholesterol (TC) levels in the normal and hypercholesterolemic male rat.
in vivo
Terbufibrol (20-200 mg/kg) is active in lowering serum TC in animals on all 3 diets, but the extent of cholesterol reduction varies in the order cholesterol (HC)>high protein and fat diet (HPF)>N (max. reductions: 154, 80, and 70%, respectively). Clofibrate (200 mg/kg) decreases TC by a maximum of 28% with the HPF-diet and 13% with the N-diet but is inactive with the HC-diet. Cholestyramine (400 mg/kg/day) is inactive in HPF-fed animals but reduces TC in HC-fed animals by 45%. With the HPF-diet nicotinic acid (200 mg/kg) is inactive. Terbufibrol lowers HDL, HDL-TC, LDL, LDL-TC and LDL-TC/PL in animals fed HPF-diet. A greater decrease of LDL-TC occurres with increasing dose. The main effect of Clofibrate (200 mg/kg) is to reduce HDL and HDL-TC and to increase LDL[1].
References
[1] Howard AN, et al. The hypocholesterolemic effect of terbufibrol and other drugs in normal and hypercholesterolemic baboons. Atherosclerosis. 1979 Apr;32(4):367-80. DOI:10.1016/0021-9150(79)90004-2
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Raw materials
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