Revizinone
- Product Name
- Revizinone
- CAS No.
- 133718-29-3
- Chemical Name
- Revizinone
- Synonyms
- R 80122;Revizinone;R 80122;R80122;R-80122;Acetamide, N-cyclohexyl-N-methyl-2-[[(E)-[phenyl(1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)methylene]amino]oxy]-
- CBNumber
- CB61117790
- Molecular Formula
- C26H29N5O3
- Formula Weight
- 459.54
- MOL File
- 133718-29-3.mol
Revizinone Property
- Boiling point:
- 627.7±65.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 4.6 mg/mL (10.01 mM)
- pka
- 2.99±0.20(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-5857
- Product name
- Revizinone
- Purity
- 98.31%
- Packaging
- 1mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- CS-5857
- Product name
- Revizinone
- Purity
- 98.31%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-5857
- Product name
- Revizinone
- Purity
- 98.31%
- Packaging
- 10mg
- Price
- $252
- Updated
- 2021/12/16
- Product number
- orb611476
- Product name
- Revizinone
- Packaging
- 5mg
- Price
- $324.7
- Updated
- 2021/12/16
- Product number
- orb611476
- Product name
- Revizinone
- Packaging
- 10mg
- Price
- $353.6
- Updated
- 2021/12/16
Revizinone Chemical Properties,Usage,Production
Uses
Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. target: phosphodiesterase (PDE)[3]; IC 50: 0.036 microM; [3] In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) was 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increased global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [4]
References
[1] Herregods L et al. Haemodynamic effects of R 80122 immediately after cardiopulmonary bypass; preliminary results. Anaesthesia. 1994 Aug;49(8):719-22. DOI:10.1111/j.1365-2044.1994.tb04409.x
[2] Schneider J et al. Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties. Naunyn Schmiedebergs Arch Pharmacol DOI:10.1007/BF00169014
[3] de Cheffoy de Courcelles D et al. Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds. J Pharmacol Exp Ther. 1992 Oct;263(1):6-14. PMID:1328613
[4] Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22 PMID:1381769
Revizinone Preparation Products And Raw materials
Raw materials
Preparation Products
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