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Clocapramine

Product Name
Clocapramine
CAS No.
47739-98-0
Chemical Name
Clocapramine
Synonyms
Clocapramina;Clocarpramine;Clocapraminum;3-chlorocarpipramine;Clocapraminum [inn-latin];Clocapramina [inn-spanish];28058-62-0 (Di-hydrochloride);65016-29-7 (Di-hydrochloride monohydrate);1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide;1-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-4-piperidino-4-piperidinecarboxamide
CBNumber
CB61178331
Molecular Formula
C28H37ClN4O
Formula Weight
481.07
MOL File
47739-98-0.mol
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Clocapramine Property

Boiling point:
662.1±55.0 °C(Predicted)
Density 
1.23 g/cm3
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
16.20±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0002063
Product name
CLOCAPRAMINE
Purity
95.00%
Packaging
5MG
Price
$498.45
Updated
2021/12/16
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Clocapramine Chemical Properties,Usage,Production

Uses

Clocapramine is an antagonist of the D2, 5-HT2A receptors.

Definition

ChEBI: Clocapramine is a dibenzooxazepine.

in vivo

Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2].

IC 50

D2 Receptor; 5-HT2A Receptor

References

[1] Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69(4):399-412. DOI:10.1254/jjp.69.399
[2] Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64. DOI:10.1038/sj.npp.1380239

Clocapramine Preparation Products And Raw materials

Raw materials

Preparation Products

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Clocapramine Suppliers

China 5 United States 1 Global 6
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Tianjin Baibei Biotechnology Co., Ltd.
Tel
15302170631
Country
CHINA
ProdList
166
Advantage
58

47739-98-0, ClocapramineRelated Search:

(1,4'-Bipiperidine)-4'-carboxamide

  • 3-chlorocarpipramine
  • 1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide
  • 1-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-4-piperidino-4-piperidinecarboxamide
  • 28058-62-0 (Di-hydrochloride)
  • 65016-29-7 (Di-hydrochloride monohydrate)
  • Clocapramina
  • Clocapramina [inn-spanish]
  • Clocapraminum
  • Clocapraminum [inn-latin]
  • Clocarpramine
  • [1,4'-Bipiperidine]-4'-carboxamide, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-
  • 47739-98-0
  • C28H37ClN4O