Tiopinac
- Product Name
- Tiopinac
- CAS No.
- 61220-69-7
- Chemical Name
- Tiopinac
- Synonyms
- Tiopinac;RS 40974;Dibenzo[b,e]thiepin-3-acetic acid, 6,11-dihydro-11-oxo-;2-(11-Oxo-6,11-dihydrodibenzo[b,e]thiepin-3-yl)aceticacid
- CBNumber
- CB61179929
- Molecular Formula
- C16H12O3S
- Formula Weight
- 284.33
- MOL File
- 61220-69-7.mol
Tiopinac Property
- Boiling point:
- 541.3±50.0 °C(Predicted)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 4.14±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- API0012657
- Product name
- TIOPINAC
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.5
- Updated
- 2021/12/16
Tiopinac Chemical Properties,Usage,Production
Uses
Tiopinac (RS 40974), a dibenzthiepin, is an orally active and highly potent anti-inflammatory and anti-pyretic agent[1].
in vivo
Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1].
References
[1] Rooks WH 2nd, et al. The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac). Agents Actions. 1980 Jun;10(3):266-73. DOI:10.1007/BF02025946
Tiopinac Preparation Products And Raw materials
Raw materials
Preparation Products
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