trans-4-Cyclohexyl-L-proline

Product Name: trans-4-Cyclohexyl-L-proline
CAS No.: 103201-78-1
Chemical Name: trans-4-Cyclohexyl-L-proline
Synonyms: H-Chpro-OH;Estreptoquinasa;Fosinopril Intermediate 2;rans-4-Cyclohexyl-L-proline;(4S)- 4-cyclohexyl-L-Proline;trans-4-Cyclohexyl-L-proline;L-Proline, 4-cyclohexyl-, (4S)-;trans-4-Cyclohexyl-L-proline USP/EP/BP;H-Chpro-OH【trans-4-Cyclohexyl-L-proline】;4-cyclohexyl-2-pyrrolidinecarboxylic acid
CBNumber: CB6119072
Molecular Formula: C11H19NO2
Formula Weight: 197.27
MOL File: 103201-78-1.mol

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trans-4-Cyclohexyl-L-proline Property

Melting point:: 260-262 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
Boiling point:: 343.9±35.0 °C(Predicted)
Density: 1.113±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.35±0.40(Predicted)
Appearance: White to off-white Solid
optical activity: -30.2°(C=0.011192 g/mL ACOH)
InChI: InChI=1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)/t9-,10+/m1/s1
InChIKey: XRZWVSXEDRYQGC-ZJUUUORDSA-N
SMILES: C(O)(=O)[C@@H]1C[C@@H](C2CCCCC2)CN1
CAS DataBase Reference: 103201-78-1(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 075217
Product name: trans-4-Cyclohexyl-L-proline
Purity: 95+%
Packaging: 1g
Price: $149
Updated: 2021/12/16

AK Scientific

Product number: S458
Product name: trans-4-Cyclohexyl-L-proline
Packaging: 1g
Price: $161
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002709
Product name: TRANS-4-CYCLOHEXYL-L-PROLINE
Purity: 95.00%
Packaging: 1G
Price: $286.65
Updated: 2021/12/16

Matrix Scientific

Product number: 075217
Product name: trans-4-Cyclohexyl-L-proline
Purity: 95+%
Packaging: 5g
Price: $438
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002709
Product name: TRANS-4-CYCLOHEXYL-L-PROLINE
Purity: 95.00%
Packaging: 2.5G
Price: $1011.6
Updated: 2021/12/16

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trans-4-Cyclohexyl-L-proline Chemical Properties,Usage,Production

Synthesis

96314-26-0

103201-78-1

The general procedure for the synthesis of (2S,4S)-4-cyclohexylpyrrolidine-2-carboxylic acid from (2S,4S)-4-phenylpyrrolidine-2-carboxylic acid was as follows: compound V (1.2 g), 5% rhodium-carbon catalyst (0.24 g), concentrated hydrochloric acid (1.2 ml), and methanol (12 ml) were added to the reaction flask sequentially. The reaction mixture was stirred and hydrogenated at 30 °C under 2.0 MPa hydrogen pressure. After 2 hours of reaction, the reaction mixture was filtered under reduced pressure. The filtrate was concentrated under reduced pressure to give a white solid product (1.11 g) in 90.0% yield.

References

[1] Patent: CN107365268, 2017, A. Location in patent: Paragraph 0016

trans-4-Cyclohexyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

Fosinopril

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trans-4-Cyclohexyl-L-proline Suppliers

China 120 India 4 United Kingdom 5 United States 10 Global 139

Shanghai ACT chemical Limited

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View Lastest Price from trans-4-Cyclohexyl-L-proline manufacturers

Career Henan Chemical Co

Product: trans-4-Cyclohexyl-L-proline 103201-78-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-05-23

103201-78-1, trans-4-Cyclohexyl-L-prolineRelated Search:

L-Phenylalanine L-Proline trans-3-phenyl-l-proline TRANS-4-PHENYL-L-PROLINE HYDROCHLORIDE,4 trans-4-Phenyl-L-proline hydrochloride,Trans-4-Phenyl-L-Proline HCl FOSINOPRIL'S INTERMEDIATE 2,TRANS-4-CYCLOHEXYL-L-PROLINE FOSINOPRIL-PHENYL-D5 SODIUM SALT Fosinoprilat-phenyl-D5 Sodium Salt Fosinopril sodium (2S,4S)-FMOC-4-CYCLOHEXYL-PYRROLIDINE-2-CARBOXYLIC ACID trans-4-Cyclohexyl-L-proline trans-4-Cyclohexyl-L-proline hydrochloride FOSINOPRILAT (2S,4S)-BOC-4-CYCLOHEXYL-PYRROLIDINE-2-CARBOXYLIC ACID Fosinopril FOSINOPRILAT SODIUM SALT

L-Proline, 4-cyclohexyl-, (4S)-

H-Chpro-OH

TRANS-4-CYCLOHEXYL-L-PROLINE (FOSINOPRIL''S INTERMEDIATE 2)

trans-4-Cyclohexyl-L-proline

Fosinopril Intermediate 2

(2S,4S)-4-cyclohexylpyrrolidine-2-carboxylic acid

(4S)- 4-cyclohexyl-L-Proline

H-Chpro-OH【trans-4-Cyclohexyl-L-proline】

4-cyclohexyl-2-pyrrolidinecarboxylic acid

rans-4-Cyclohexyl-L-proline

trans-4-Cyclohexyl-L-proline USP/EP/BP

(Trans)-4-CyclohexylprolineQ: What is (Trans)-4-Cyclohexylproline Q: What is the CAS Number of (Trans)-4-Cyclohexylproline Q: What is the storage condition of (Trans)-4-Cyclohexylproline

Estreptoquinasa

103201-78-1

10321-78-1

C11H13NO2