sordarin sodium salt
- Product Name
- sordarin sodium salt
- CAS No.
- 463356-00-5
- Chemical Name
- sordarin sodium salt
- Synonyms
- Sordarin sodium;SORDARIN SODIUM SALT
- CBNumber
- CB61216297
- Molecular Formula
- C27H39O8.Na
- Formula Weight
- 514.587
- MOL File
- 463356-00-5.mol
sordarin sodium salt Property
- storage temp.
- -20°C
- solubility
- H2O: soluble ≤10mg/mL
- form
- solid
- color
- White to off-white
- biological source
- Sordaria araneosa
- Water Solubility
- H2O: soluble ≤10mg/mL
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- S1442
- Product name
- Sordarin sodium salt
- Purity
- from Sordaria araneosa, ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $573
- Updated
- 2025/07/31
- Product number
- 26255
- Product name
- Sordarin (sodium salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 26255
- Product name
- Sordarin (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $481
- Updated
- 2024/03/01
- Product number
- API0008577
- Product name
- SORDARIN SODIUM SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $966.86
- Updated
- 2021/12/16
sordarin sodium salt Chemical Properties,Usage,Production
Description
Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa. It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml). It inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml).
Uses
Sordarin Sodium Salt is a selective fungal EF-2 inhibitor.
Biochem/physiol Actions
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C.?albicans, C.?glabrata, and C.?neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.
References
[1] J M DOMíNGUEZ J J M M G Gómez Lorenzo. Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid.[J]. The Journal of Biological Chemistry, 1999, 274 32: 22423-22427. DOI: 10.1074/jbc.274.32.22423
[2] J M DOMíNGUEZ. Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts.[J]. Antimicrobial Agents and Chemotherapy, 1998, 42 9: 2274-2278. DOI: 10.1128/aac.42.9.2274
sordarin sodium salt Preparation Products And Raw materials
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