sordarin sodium salt

Product Name: sordarin sodium salt
CAS No.: 463356-00-5
Chemical Name: sordarin sodium salt
Synonyms: Sordarin sodium
CBNumber: CB61216297
Molecular Formula: C27H39O8.Na
Formula Weight: 514.587
MOL File: 463356-00-5.mol

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sordarin sodium salt Property

storage temp.: -20°C
solubility: H2O: soluble ≤10mg/mL
form: solid

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S1442
Product name: Sordarin sodium salt
Purity: from Sordaria araneosa, ≥98% (HPLC), solid
Packaging: 5mg
Price: $531
Updated: 2024/03/01

Cayman Chemical

Product number: 26255
Product name: Sordarin (sodium salt)
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 26255
Product name: Sordarin (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $481
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0008577
Product name: SORDARIN SODIUM SALT
Purity: 95.00%
Packaging: 5MG
Price: $966.86
Updated: 2021/12/16

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sordarin sodium salt Chemical Properties,Usage,Production

Description

Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa. It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC₅₀ = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC₅₀s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC₅₀ = >100 μg/ml). It inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml).

Uses

Sordarin Sodium Salt is a selective fungal EF-2 inhibitor.

Biochem/physiol Actions

Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C.?albicans, C.?glabrata, and C.?neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

sordarin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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sordarin sodium salt Suppliers

China 6 United States 5 Global 11

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19743
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9154
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.com
Country: China
ProdList: 24246
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

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Sordarin sodium

463356-00-5