2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

Product Name: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
CAS No.: 484-78-6
Chemical Name: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
Synonyms: NSC 96400;Paralysin II;3-hydroxykynurenine;DL-Hydroxykynurenine;rac 3-Hydroxy Kynurenine;3-(3-Hydroxyanthraniloyl)alanine;REF DUPL: DL-3-Hydroxykynurenine;Benzenebutanoic acid, α,2-diamino-3-hydroxy-γ-oxo-;2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;REF DUPL: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
CBNumber: CB61236011
Molecular Formula: C10H12N2O4
Formula Weight: 224.21
MOL File: 484-78-6.mol

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2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Property

Melting point:: 213 °C (decomp)
Boiling point:: 365.61°C (rough estimate)
Density: 1.2995 (rough estimate)
refractive index: 1.6620 (estimate)
storage temp.: 2-8°C
solubility: DMF: 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 0.5 mg/ml
form: A crystalline solid
pka: 2.16±0.23(Predicted)
color: Light yellow to yellow
Stability:: Hygroscopic

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H1771
Product name: 3-Hydroxy-DL-kynurenine
Packaging: 25mg
Price: $167
Updated: 2024/03/01

Sigma-Aldrich

Product number: H1771
Product name: 3-Hydroxy-DL-kynurenine
Packaging: 100mg
Price: $499
Updated: 2024/03/01

Sigma-Aldrich

Product number: 78047
Product name: 3-Hydroxy-DL-kynurenine
Purity: analyticalstandard
Packaging: 10MG
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: 78047
Product name: 3-Hydroxy-DL-kynurenine
Purity: analyticalstandard
Packaging: 50MG
Price: $339
Updated: 2022/05/15

Cayman Chemical

Product number: 27778
Product name: 3-hydroxy-DL-Kynurenine
Packaging: 10mg
Price: $68
Updated: 2024/03/01

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2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Chemical Properties,Usage,Production

Uses

3-Hydroxykynurenine is a metabolite of tryptophan. ential endogenous neurotoxin.

Uses

3-Hydroxy-DL-kynurenine is a tryptophan metabolite. Could be associated with symptoms in Parkinson''s disease.

Uses

3-Hydroxy-DL-kynurenine has been used:

as a substrate for the recombinant human kynureninase assay
as a reference standard in tandem mass spectrometry (MS/MS) analysis
as a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients

Definition

ChEBI: A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.

General Description

3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine?by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively.

Biochem/physiol Actions

3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia.

2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Suppliers

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484-78-6, 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acidRelated Search:

Poly-L-aspartic acid DL-KYNURENINE

2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

3-hydroxykynurenine

Paralysin II

REF DUPL: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

REF DUPL: DL-3-Hydroxykynurenine

3-(3-Hydroxyanthraniloyl)alanine

NSC 96400

rac 3-Hydroxy Kynurenine

3-Hydroxy-DL-kynurenine,rac 3-Hydroxy Kynurenine Hydrochloride Salt

Benzenebutanoic acid, α,2-diamino-3-hydroxy-γ-oxo-

DL-Hydroxykynurenine

484-78-6