Amicetin-A

Product Name: Amicetin-A
CAS No.: 17650-86-1
Chemical Name: Amicetin-A
Synonyms: amicetin;Amicetin-A;Amomycin A;Benzamide, 4-[[(2S)-2-amino-3-hydroxy-2-methyl-1-oxopropyl]amino]-N-[1-[(2R,5S,6R)-5-[[4,6-dideoxy-4-(dimethylamino)-α-D-glucopyranosyl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]-1,2-dihydro-2-oxo-4-pyrimidinyl]-
CBNumber: CB61244964
Molecular Formula: C29H42N6O9
Formula Weight: 618.68
MOL File: 17650-86-1.mol

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Amicetin-A Property

Melting point:: 244-245°
alpha: D24 +116.5° (c = 0.5 in 0.1N HCl)
Boiling point:: 660.6°C (rough estimate)
Density: 1.2721 (rough estimate)
refractive index: 1.6400 (estimate)
pka: pKa = 10.4, 7.0(at 25℃)

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Safety

Toxicity: LD50 of citrate complex, pH 6 (mg/kg) in mice: ~90 i.v., 600-700 s.c.; in rats: ~200 i.v., ~600 s.c. (DeBoer)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0025360
Product name: AMICETIN-A
Purity: 95.00%
Packaging: 5MG
Price: $500.71
Updated: 2021/12/16

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Amicetin-A Chemical Properties,Usage,Production

Uses

Amicetin is a potent antibiotic. Amicetin shows antibiotic activities against gram-positive bacteria. Amicetin inhibits protein synthesis[1][2][3].

Enzyme inhibitor

These pyrimidine-containing glycoside antibiotic (FWAmicetin-A = 617.69 g/mol (free base); CAS 17650-86-1; FWAmicetin-B = 532.59 g/mol (free base)) from Streptomyces vinaceus-drappus and S. fasciculatus inhibits protein biosynthesis, exerting its bacteriostatic most potently on Grampositive bacteria. Amicetin B, also called plicacetin, was isolated from Streptomyces plicatus and has the identical structure minus the amethylseryl residue. It is weaker in action compared to amicetin A. Target(s): peptidyltransferase; peptidyl-tRNA hydrolase, or aminoacyl-tRNA hydrolase; ribonuclease P; protein biosynthesis.

References

[1] HINUMA Y, et al. An amicetin (sacromycin) from Streptomyces sp. No. 5223. Studies on Streptomyces antibiotics. XXXVI. J Antibiot (Tokyo). 1955 Nov;8(5):148-52. PMID:13306673
[2] Fu, J., et al. Total Synthesis of Nucleoside Antibiotics Amicetin, Plicacetin, and Cytosaminomycin A—D. Chinese Journal of Chemistry, 2021, 39(10), 2679-2684.
[3] Ennis, H. L. et, al. Polysome Metabolism in Escherichia coli: Amicetin, an Antibiotic That Stabilizes Polysomes. Antimicrobial Agents and Chemotherapy, 1972, 1(3), 204-209. doi:10.1128/aac.1.3.204. DOI:10.1128/AAC.1.3.204

Amicetin-A Preparation Products And Raw materials

Raw materials

Preparation Products

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Amicetin-A Suppliers

China 4 United States 2 Global 6

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 18679456698
Email: mingxinzhu@huidabiotech.com
Country: China
ProdList: 2975
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Zhejiang Huida Biotech Co., LTD

Tel: 0571-0571-89903882 15990081639
Email: sunshixuan@huidabiotech.com
Country: China
ProdList: 3705
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
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Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

Tel: +8618791163155
Email: 18791163155@163.com
Country: China
ProdList: 3397
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17650-86-1, Amicetin-ARelated Search:

Amicetin-A 2(1H)-Pyrimidinone, 4-(methylamino)- (9CI) Cytosine 2,3-DIHYDROPYRIMIDIN-4-AMINE ANTIMYCIN A

Amicetin-A

amicetin

Benzamide, 4-[[(2S)-2-amino-3-hydroxy-2-methyl-1-oxopropyl]amino]-N-[1-[(2R,5S,6R)-5-[[4,6-dideoxy-4-(dimethylamino)-α-D-glucopyranosyl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]-1,2-dihydro-2-oxo-4-pyrimidinyl]-

Amomycin A

17650-86-1

C29H42N6O9