ChemicalBook > CAS DataBase List > 6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid
6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid
- Product Name
- 6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid
- CAS No.
- 183293-82-5
- Chemical Name
- 6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid
- Synonyms
- PD-72953;gemcabene;Gemcabene, 10 mM in DMSO;6,6'-Oxybis(2,2-dimethylhexanoic) acid;Hexanoic acid, 6,6'-oxybis[2,2-dimethyl-;Gemcabene,Inhibitor,PD72953,inhibit,PD 72953;6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid;6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethyl-hexanoic acid
- CBNumber
- CB61258501
- Molecular Formula
- C16H30O5
- Formula Weight
- 302.41
- MOL File
- 183293-82-5.mol
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6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid Property
- Melting point:
- 49-51 °C
- Boiling point:
- 453.6±30.0 °C(Predicted)
- Density
- 1.048±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 125 mg/mL (413.35 mM)
- pka
- 4.52±0.45(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3124
- Product name
- Gemcabene
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $69.54
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML3124
- Product name
- Gemcabene
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $295
- Updated
- 2025/07/31
American Custom Chemicals Corporation
- Product number
- CHM1015761
- Product name
- 6-(5-CARBOXY-5-METHYL-HEXOXY)-2,2-DIMETHYL-HEXANOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.9
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC12392
- Product name
- Gemcabene
- Purity
- >98%
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC12392
- Product name
- Gemcabene
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1100
- Updated
- 2021/12/16
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6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid Chemical Properties,Usage,Production
Uses
Atherosclerosis therapy; treatment of lipoprotein disorders.
Biological Activity
Gemcabene is an orally available lipid-regulating compound th at induces both a cholesterol and triglyceride reduction by a mechanism of action not linked to agonist or antagonist activity on the PPAR-α receptors. Gemcabene down-regulates apoC-III expression. Gemcabene is primarily metabolized (glucuronidation) by UDP-glucuronosyltransferase2B7 (UGT2B7). Thus, is often used as a UGT2B7 substrate.
6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid Suppliers
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