2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Property

Melting point:

123-125°C

Boiling point:

736.4±70.0 °C(Predicted)

Density 

1.274±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

3.82±0.10(Predicted)

form 

Solid

color 

Off-White

EPA Substance Registry System

Glycine, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]- (331741-94-7)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H402Harmful to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Chemical Properties,Usage,Production

Description

Muraglitazar is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ (EC₅₀s = 0.32 and 0.11 μM, respectively). It is selective for PPARα/γ over other nuclear receptors, including PPARδ, RXRα, RARs, estrogen receptor α (ERα), ERβ, androgen receptor (AR), and progesterone receptor (PR). Muraglitazar (50 μM) reduces the size of lipid droplets in oleic acid-treated HepaRG human hepatocytes. It reduces plasma levels of glucose, triglycerides, free fatty acids, and insulin by 54, 33, 62, and 48%, respectively, in db/db mice when administered at a dose of 10 mg/kg per day. Muraglitazar (10 mg/kg per day) reduces plasma levels of glucose, triglycerides, and cholesterol in diet-induced obese mice. Muraglitazar also inhibits LPS-induced increases in nitric oxide (NO) production and IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) protein levels in J774 murine macrophages in a concentration-dependent manner. It inhibits carrageenan-induced paw edema in mice when administered at doses ranging from 12.5 to 50 mg/kg.

Chemical Properties

Off-White Solid

Uses

It is a peroxisome proliferator-activated receptor (PPAR) a/ dual agonist

Uses

It is a peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist.

Definition

ChEBI: Muraglitazar is a member of 1,3-oxazoles.

in vitro

in murine j774 macrophages, muraglitazar dose-dependently reduced lipopolysaccharide-induced inducible nitric oxide synthase (inos) expression, nitrous oxide, il-6 and tnfα production and showed no effect on cell viability at the given concentration. muraglitazar decreased the levels of inos mrna expression, suggesting that the suppressive effect of muraglitazar was mediated at the level of inos transcription. in human hek293 cells, muraglitazar did not affect the nuclear levels of nf- κb p65 compared to the control and did not modulate nf-κb-mediated transcription [1].

in vivo

male charles river mice were administrated orally with muraglitazar at a dose of 12.5, 25, 50 mg/kg for six hours. muraglitazar, in a dose-dependent fashion, prevented the development of oedema. in addition, muraglitazar dose-dependently attenuated inflammation and decreased the levels of il-6, tnfα and inos mrna [1].

IC 50

0.42 μm: shows agonistic activity at peroxisome proliferator-activated receptor α (pparα)

References

[1]. paukkeri, e., leppnen, t., lindholm, m., yam, m., asmawi, m., & kolmonen, a. et al. anti-inflammatory properties of a dual ppargamma/alpha agonist muraglitazar in in vitro and in vivo models. arthritis research & therapy. 2013;15(2): r51.